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COMT Val158Met Modulates Association Between Brain White Matter Architecture and IQ

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收录情况： ◇ SCIE

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机构： [1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P.R. China [2]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, P.R. China [3]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P.R. China

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关键词： catechol-o-methyltransferase dopamine intelligence diffusion tensor imaging white matter

摘要：

The intelligence quotient (IQ) is typically associated with the architecture of gray and white matter in specific brain regions, and this association appears to be genetically based. However, specific sources of genetic variation for the association have not been studied extensively. Using diffusion tensor imaging in 15 mental retardation patients and 80 healthy volunteers, we studied the association between white matter architecture and IQ and also investigated the effects of COMT val158met on this association. The results showed that fractional anisotropy (FA) values in the prefrontal lobe and the hippocampus formation were associated with IQ and that val158met may affect this association. Subjects who were val homozygous showed steeper slopes for regression of the FA value on IQ than met carriers. Our findings suggest that COMT val158met may contribute to intelligence by affecting the association between IQ and the white matter architecture in the prefrontal lobe and the hippocampal formation. (C) 2008 Wiley-Liss, Inc.

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出版当年[2008]版：

大类 | 2 区医学

小类 | 2 区精神病学 3 区遗传学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区遗传学 3 区精神病学

JCR分区：

出版当年[2007]版：

Q1 PSYCHIATRY Q1 GENETICS & HEREDITY

最新[2023]版：

Q3 GENETICS & HEREDITY Q3 PSYCHIATRY Q4 GENETICS & HEREDITY

影响因子： 1.6 最新[2023版] 2.7 最新五年平均 4.224 出版当年[2007版] 4.209 出版当年五年平均 4.463 出版前一年[2006版] 3.932 出版后一年[2008版]

第一作者：

第一作者机构： [1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P.R. China [3]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P.R. China

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通讯机构： [1]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P.R. China

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