机构：[a]Department of Neurology and Neurobiology,Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, P.R. China神经内科神经变性病教育部重点实验室首都医科大学宣武医院[b]Cell Therapy Center, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, P.R. China神经变性病教育部重点实验室首都医科大学宣武医院
The aims of this study were to determine (i) whether striatal neuropeptides (dynorphin, enkephalin 1, substance P, cholecystokinin) and dopamine receptors 1 and 2 (D1r and D2r) are regulated by the molecular clock; and (ii) when their oscillations start after birth. Twenty-four-hour mRNA oscillations of these genes were evaluated in the mouse striatum at early postnatal stage (postnatal day 3), preweaning stage (postnatal day 14), and adult (postnatal day 60). At P3, no daily oscillations were observed. A significant time effect was present for D2r, dynorphin, and enkephalin 1 at P14, and for all genes except D1r, at P60. In conclusion, circadian expression of these neurotransmitter-related genes develops in the mouse striatum after birth gradually. NeuroReport 21:79-83 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
基金：
the National Natural Science Foundation of China (30400148, 30430280)
The National 973 Project grant of China (2006CB500701,2006CB943703, 2007CB947704)
The national 863 Project grant of China (2006AA02A408, 2006AA02A112,2006AA02A114)
Scientific project of Beijing municipal science & technology commission (D07050701350703,D07050701350706)
第一作者机构：[a]Department of Neurology and Neurobiology,Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, P.R. China
通讯作者：
通讯机构：[*1]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Yanning Cai,Hui Ding,Ning Li,et al.Oscillation development for neurotransmitter-related genes in the mouse striatum[J].NEUROREPORT.2010,21(2):79-83.doi:10.1097/WNR.0b013e32832ff30e.
APA：
Yanning Cai,Hui Ding,Ning Li,Yuxin Chai,Yanli Zhang&Piu Chan.(2010).Oscillation development for neurotransmitter-related genes in the mouse striatum.NEUROREPORT,21,(2)
MLA：
Yanning Cai,et al."Oscillation development for neurotransmitter-related genes in the mouse striatum".NEUROREPORT 21..2(2010):79-83
