机构：[a]College of Information Science and Technology, Beijing Normal University, Beijing, China, 100875[b]Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 100875[c]Banner Alzheimer’s Institute and Banner Good Samaritan PET Center, Phoenix, USA, AZ 85006[d]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053放射科首都医科大学宣武医院
Gray matter volume and cortical thickness are two important indices widely used to detect neuropathological changes in brain structural magnetic resonance imaging. Using optimized voxel-based morphometry (VBM) protocol and surface-based cortical thickness measure, this study comprehensively investigated the regional changes in cortical gray matter volume and cortical thickness in Alzheimer's disease (AD). Thirteen patients with AD and fourteen age-and gender-matched healthy controls were included in this study. Results showed that voxel-based gray matter volume and cortical thickness reductions were highly correlated in the temporal lobe and its medial structure in AD. Moreover significant reduced cortical regions of gray matter volume were obviously more than that of cortical thickness. These findings suggest that gray matter volume and cortical thickness, as two important imaging markers, are effective indices for detecting the neuroanatomical alterations and help us understand the neuropathology from different views in AD.
基金：
Key Program of National Natural Science Foundation of China (60931003), the National Natural Science Foundation of China (90820019, 60805040).
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[a]College of Information Science and Technology, Beijing Normal University, Beijing, China, 100875[b]Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 100875
通讯作者：
通讯机构：[a]College of Information Science and Technology, Beijing Normal University, Beijing, China, 100875[b]Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, 100875
推荐引用方式(GB/T 7714)：
Xiaojuan Guo,Ziyi Li,Kewei Chen,et al.Mapping gray matter volume and cortical thickness in Alzheimer's disease[J].MEDICAL IMAGING 2010: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING.2010,7626:doi:10.1117/12.844070.
APA：
Xiaojuan Guo,Ziyi Li,Kewei Chen,Li Yao,Zhiqun Wang&Kuncheng Li.(2010).Mapping gray matter volume and cortical thickness in Alzheimer's disease.MEDICAL IMAGING 2010: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING,7626,
MLA：
Xiaojuan Guo,et al."Mapping gray matter volume and cortical thickness in Alzheimer's disease".MEDICAL IMAGING 2010: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING 7626.(2010)
