机构：[a]College of Information Science and Technology, Beijing Normal University, Beijing, China[b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China[c]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China放射科首都医科大学宣武医院[d]Laboratory of Magnetic Resonance Imaging, Beijing 306 Hospital, Beijing, China[e]Banner Alzheimer’s Institute and Banner Good Samaritan PET Center, 1111 E. McDowell Road, Phoenix, AZ 85006, USA
Using the study-specific templates and optimized voxel-based morphometry (VBM), this study investigated abnormalities in gray and white matter to provide depiction of the concurrent structural changes in 13 patients with Alzheimer's disease (AD) compared with 14 age- and sex-matched normal controls. Consistent with previous studies, patients with AD exhibited significant gray matter volume reductions mainly in the hippocampus, parahippocampal gyrus, insula, superior/middle temporal gyrus, thalamus, cingulate gyrus, and superior/inferior parietal lobule. In addition, white matter volume reductions were found predominately in the temporal lobe, corpus callosum, and inferior longitudinal fasciculus. Furthermore, a number of additional white matter regions such as precentral gyrus, cingulate fasciculus, superior and inferior frontal gyrus, and sub-gyral in parietal lobe were also affected. The pattern of gray and white matter volume reductions helps us understand the underlying pathologic mechanisms in AD and potentially can be used as an imaging marker for the studies of AD in the future. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
基金：
National Natural Science Foundation of China (60805040, 90820019 and 60628101), the National Institute of Mental Health, US (RO1MH57899),
the National Institute on Aging, US (9R01AG031581-10 and P30AG19610) and the state of Arizona.
第一作者机构：[a]College of Information Science and Technology, Beijing Normal University, Beijing, China[b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
通讯作者：
通讯机构：[e]Banner Alzheimer’s Institute and Banner Good Samaritan PET Center, 1111 E. McDowell Road, Phoenix, AZ 85006, USA
推荐引用方式(GB/T 7714)：
Xiaojuan Guo,Zhiqun Wang,Kuncheng Li,et al.Voxel-based assessment of gray and white matter volumes in Alzheimer's disease[J].NEUROSCIENCE LETTERS.2010,468(2):146-150.doi:10.1016/j.neulet.2009.10.086.
APA：
Xiaojuan Guo,Zhiqun Wang,Kuncheng Li,Ziyi Li,Zhigang Qi...&Kewei Chen.(2010).Voxel-based assessment of gray and white matter volumes in Alzheimer's disease.NEUROSCIENCE LETTERS,468,(2)
MLA：
Xiaojuan Guo,et al."Voxel-based assessment of gray and white matter volumes in Alzheimer's disease".NEUROSCIENCE LETTERS 468..2(2010):146-150
