机构：[a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China神经变性病教育部重点实验室首都医科大学宣武医院实验动物室[b]School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China
Oxidative stress-induced cell damage has been implicated in a variety of neurodegenerative disorders. Morroniside, an iridorid glycoside isolated from Cornus officinalis Sieb. Et Zucc., has shown potent antioxidant properties. The present study investigated the protective actions of morroniside against the cytotoxicity produced by exposure to H2O2 (300-500 mu M) in SH-SY5Y cells. Intracellular accumulation of Ca2+, and decreases in mitochondrial membrane potential (MMP) caused by added H2O2 were reduced by morroniside. Incubation of cells with H2O2 caused a marked decrease in superoxide dismutase (SOD) activity; this decrease was significantly inhibited by morroniside. In addition, the percentage of cells undergoing H2O2-induced apoptosis was decreased, dose dependently, in the presence of morroniside. These results suggest that morroniside has protective effects against oxidative stress-induced neurotoxic processes. (C) 2009 Elsevier B.V. All rights reserved.
基金：
Program Foundation: Chinese “973” program foundation (No: 2003CB517104); National Natural Science Foundation of China (No: 30740053);
Beijing Natural Science Foundation, China (No: 7062031); Base-clinical Foundation of Capital Medical University, China (No: 2006JL05);
and the Key Laboratory for Neurodegenerative Disease from the Ministry of Education Foundation, China (No: 200704, 200802).
第一作者机构：[a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
通讯作者：
通讯机构：[a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Wen Wang,Fangling Sun,Yi An,et al.Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2009,613(1-3):19-23.doi:10.1016/j.ejphar.2009.04.013.
APA：
Wen Wang,Fangling Sun,Yi An,Houxi Ai,Li Zhang...&Lin Li.(2009).Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity.EUROPEAN JOURNAL OF PHARMACOLOGY,613,(1-3)
MLA：
Wen Wang,et al."Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity".EUROPEAN JOURNAL OF PHARMACOLOGY 613..1-3(2009):19-23
