机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China老年医学科首都医科大学宣武医院[2]Department of Laboratory Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China
This study aimed to retrospectively analyze the effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on adolescent cynomolgus monkeys. A total of 12 monkeys (six STZ-DM and six controls) were monitored for fasting glucose levels and locomotor activities, tested for hematological and serum parameters, measured for body weight and somatometric values. Fasting glucose was maintained at high levels in STZ-DM monkeys. At the age when normal adolescent monkeys dramatically increased their weight, STZ-DM led to the retardation of weight increase in diabetic monkeys. Moreover, STZ-DM monkeys showed abnormal lipid levels and somatometric measurements. In locomotor activity test, STZ-DM monkeys were more active than control ones. Long-term STZ-DM disrupts the normal growth of young monkeys and interferes with some aspects of hormone, lipid metabolism and physical activities. Mean plasma glucose (MPG) appeared to be an important factor in physical activity abnormalities of STZ-DM monkeys.
基金：
a grant from National 863 Program (2006AA02A116), National Science & Technology Pillar Program (2007BAI33B01) and 973 Program (2007CB947700).
第一作者机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China
通讯作者：
通讯机构：[*]Xuanwu Hospital, Capital University of Medical Science, 45 Changchun Street, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
D. Wu,C. Zou,F. Yue,et al.The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca Fascicularis) monkeys[J].JOURNAL OF MEDICAL PRIMATOLOGY.2009,38(1):15-22.doi:10.1111/j.1600-0684.2008.00300.x.
APA：
D. Wu,C. Zou,F. Yue,X. Li,S. Li&Y.A. Zhang.(2009).The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca Fascicularis) monkeys.JOURNAL OF MEDICAL PRIMATOLOGY,38,(1)
MLA：
D. Wu,et al."The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca Fascicularis) monkeys".JOURNAL OF MEDICAL PRIMATOLOGY 38..1(2009):15-22
