机构：[1]Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing,[2]Neurology Department of the First Affiliated Hospital, Guangxi Medical University, Nanning,[3]Beijing Tiantan Hospital of the Capital University of Medical Sciences,[4]Beijing Xuanwu Hospital of the Capital University of Medical Sciences, Beijing, China首都医科大学宣武医院
Objective: To investigate the expression of monocyte chemoattractant protein-1 (MCP-1) in the brain tissue of patients with intractable epilepsy (IE) and to explore its role in the pathogenesis of IE. Material: Patients with IE were collected from the Department of Neurosurgery of several Chinese hospitals between 2002 and 2005. The average age of these 40 patients was 23.65 +/- 10.14 (X +/- SD) years (11 - 58 years), with 19 males and 21 females. In addition to the typical symptoms and distinct EEG features of epilepsy, all recruited patients met the requirements of intractable epilepsy. Methods: Oil the basis of positive results obtained from gene chip analysis, the expression of MCP-1 was first investigated in the brain tissue of IE patients (40 cases) using Western Blotting and immunohistochemistry and then compared with the controls. Results: Gene chip scanning demonstrated that expression of MCP-1 mRNA was upregulated in the brain tissue of patients with IE. Western Blotting and immunohistochemical experiments further confirmed that, as compared with that in the control group, expression of MCP-1 protein was significantly increased in the I E patients (p < 0.05). Conclusion: These results suggest that MCP-1 are involved in the pathogenesis of IE.
基金：
grants from Beijing Tiantan Hospital of the Capital University of Medical Sciences.
第一作者机构：[1]Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing,[2]Neurology Department of the First Affiliated Hospital, Guangxi Medical University, Nanning,
通讯作者：
通讯机构：[*]Department of Neurology The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
推荐引用方式(GB/T 7714)：
Y. Wu,X. Wang,X. Mo,et al.Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy[J].CLINICAL NEUROPATHOLOGY.2008,27(2):
APA：
Y. Wu,X. Wang,X. Mo,Z. Xi,F. Xiao...&J. Zhang.(2008).Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy.CLINICAL NEUROPATHOLOGY,27,(2)
MLA：
Y. Wu,et al."Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy".CLINICAL NEUROPATHOLOGY 27..2(2008)
