机构：[a]Department of Psychology, Peking University, Beijing 100871, China[b]Pain Clinic of Xuanwu Hospital, Beijing 100053, China疼痛科首都医科大学宣武医院[c]Department of Occupational Health, Shanxi Medical University, Taiyuan 030001, China[d]Department of Occupational and Environmental Health, Peking University, Beijing 100083, China
The neurotoxicity of manganese has been demonstrated by many researches. But few reports have been found on its immunotoxicity in manganese-exposed workers. Here we selected welding workers (aged 34 years) as Mn-exposed subjects. They have been exposed to manganese for 16 years. The control group was from a flour plant. The average concentrations of Mn, Cd, Fe and Ni in work place were 138.40 +/- 11.60 mu g/m(3), 581.40 +/- 45.32 mu g/m(3), 3.84 +/- 0.53 mu g/m(3) and 12.64 +/- 2.80 ng/m(3), respectively. Blood Mn (4.84 mu g/dl) of welding workers was higher than that of the control group (1.92 mu g/dl). Neurobehavioral core test battery (NCTB) recommended by WHO was conducted on the subjects and found that the scores of negative emotions, such as confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety, were higher in welding workers. Visual simple reaction time and the fast simple reaction time were shorter than that of the control group. The numbers of digital span, forward digital span, backward digital span and digital symbol decreased in welding workers compared with control group. Monoamine neurotransmitters and their metabolism substances in urine were tested by HPLC-ultraviolet. NE, E, MHPG, HVA, DA, DOPAC and 5-HT in the urine of Mn-exposed group had no significant changes while 5-HIAA in Mn-exposed group had significantly decreased compared with that of the control group. Lymphocyte subsets of the subjects were determined by Flow Cytometer. CD3(+) T cell, CD4(+)CD8(-) T cell, CD4(-)CD8(+) T cell, CD4(+)CD45RO(-) "virgin" lymphocytes, CD4(+)CD45RO(+) "memory" lymphocytes, and CD3(-)CD19(+) B cell had no significant changes compared with the control group. The results showed that long-term exposure to manganese in welding might have adverse effects on mood state, neurobehavior, and peripheral neurotransmitters. However, they had no effects on lymphocyte subsets parameters. (c) 2005 Elsevier Inc. All rights reserved.
基金：
the grants from National Natural Science Foundation of China (No. 30400135 and No. 30471437).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2005]版：
大类|3 区医学
最新[2025]版：
大类|3 区医学
小类|2 区药学3 区医学：研究与实验
JCR分区：
出版当年[2004]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[a]Department of Psychology, Peking University, Beijing 100871, China
通讯作者：
通讯机构：[a]Department of Psychology, Peking University, Beijing 100871, China
推荐引用方式(GB/T 7714)：
Hong Yuan,Shuchang He,Mingwei He,et al.A comprehensive study on neurobehavior, neurotransmitters and lymphocyte subsets alteration of Chinese manganese welding workers[J].LIFE SCIENCES.2006,78(12):1324-1328.doi:10.1016/j.lfs.2005.07.008.
APA：
Hong Yuan,Shuchang He,Mingwei He,Qiao Niu,Lei Wang&Sheng Wang.(2006).A comprehensive study on neurobehavior, neurotransmitters and lymphocyte subsets alteration of Chinese manganese welding workers.LIFE SCIENCES,78,(12)
MLA：
Hong Yuan,et al."A comprehensive study on neurobehavior, neurotransmitters and lymphocyte subsets alteration of Chinese manganese welding workers".LIFE SCIENCES 78..12(2006):1324-1328
