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Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium

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机构： [1]Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China [2]Institute of Neuroscience, Soochow University, Suzhou 215004, China [3]Department of Anesthes iology and Pain Medicine, University of California Davis, Davis, CA 95616, USA.

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关键词： Lipopolysaccharide Myocardium Nuclear-factor-κB Parthenolide

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Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were injected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo. © 2012 The Editorial Board of Journal of Biomedical Research.

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大类 | 4 区医学

小类 | 4 区医学：研究与实验

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通讯机构： [*1]Departments of Anesthesiology, the Second Affiliated Hospital of Soochow Univer-sity, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, China. [*2]Department of Anesthesiology and Pain Medicine, University of Cali-fornia Davis, Davis, CA 95616, USA.

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