The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer
机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 ChangChun Road, Beijing 100053, China.医技科室检验学部医技科室检验科江苏省人民医院[2]Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.内科系统肿瘤科江苏省人民医院
At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated with extensive tumors and poor survival for patients with cervical cancer treated with definitive CCRT. SCC Ag levels can be used to help physicians make decisions regarding surgery, avoiding the complications of double treatment modalities. Elevated SCC Ag is associated with radiotherapy resistance, and the rate of SCC Ag reduction during CCRT can predict tumor response after treatment. Moreover, the failure of SCC Ag levels to normalize posttreatment can predict tumor relapse, with a specificity higher than 70%, and adjuvant therapies should be considered for these patients. SCC Ag also plays an important role in the early detection of tumor relapse in patients with cervical cancer during follow-up after CCRT, with high sensitivity and good cost-effectiveness.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区核医学4 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区核医学3 区肿瘤学
JCR分区：
出版当年[2017]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3ONCOLOGY
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ONCOLOGY
第一作者机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 ChangChun Road, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, 45 ChangChun Road, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Fu Jingxuan,Wang Weiping,Wang Yidan,et al.The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer[J].RADIATION ONCOLOGY.2019,14(1):doi:10.1186/s13014-019-1355-4.
APA：
Fu, Jingxuan,Wang, Weiping,Wang, Yidan,Liu, Chengeng&Wang, Peichang.(2019).The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer.RADIATION ONCOLOGY,14,(1)
MLA：
Fu, Jingxuan,et al."The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer".RADIATION ONCOLOGY 14..1(2019)
