In the virtual simulation training system for interventional surgery, most people focus on how to model blood vessel, catheter and guide wire. However, little research has been done on the effect of intravascular blood on interventional surgery. Blood is a kind of viscous fluid, so as the catheter or guide wire advances, retreats, or rotates through the blood vessel, the blood produces a kind of viscous force in the movement of the catheter or guide wire. It can affect the accuracy of the operation. In order to realize real simulation, firstly, the Smoothed Particle Hydrodynamics (SPH) method is applied to the study to simulate physical blood flow. Secondly, the Marching Cube method is adopted to render physical model, which can establish a good blood flow model. The method can also be used to simulate bleeding on organs or skin surfaces. Finally, we achieve the blood flow in blood vessel which is modeled by tensor - mass method. The experimental results show that the SPH method for blood simulation has a very real effect, and the simulation of intravascular blood flow is of great significance for the further study of interventional surgery. © 2019 IEEE.