机构:[1]Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, P. R. China E-mail: tiandl@buaa.edu.cn[2]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Beijing Children’s Hospital, Beijing 100045, P. R. China临床科室耳鼻咽喉头颈外科首都医科大学附属北京儿童医院[3]School of Materials Science and Engineering, Beihang University, Beijing 100191, China[4]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University
Anisotropic microstructures are widely used by being cleverly designed to achieve important functions. Mammals' respiratory tract is filled with dense cilia that rhythmically swing back and forth in a unidirectional wave to propel mucus and harmful substances out of the lung through larynx. Inspired by the ciliary structure and motion mechanism of the respiratory tract systems, a viscoelastic microsphere transporting strategy based on integration of airway cilium-like structure and magnetically responsive flexible conical arrays is demonstrated. Under external magnetic fields, the viscoelastic microspheres can be directionally and continuously transported alongside the swing of the cilia-like arrays that contain magnetic particles. This work provides a promising route for the design of advanced medical applications in directional transport of microspheres, drug delivery systems, ciliary dyskinesia treating, and self-cleaning without liquid.
基金:
National Basic Research Program of ChinaNational Basic Research Program of China [2013CB933003]; Beijing Young Talent Support Program; 111 projectMinistry of Education, China - 111 Project; Beijing Nova ProgramBeijing Municipal Science & Technology Commission; Beijing Natural Science FoundationBeijing Natural Science Foundation [L160003]; Chinese National Natural Science FoundationNational Natural Science Foundation of China [21671012]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities
第一作者机构:[1]Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, P. R. China E-mail: tiandl@buaa.edu.cn
通讯作者:
通讯机构:[1]Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, P. R. China E-mail: tiandl@buaa.edu.cn[4]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University
推荐引用方式(GB/T 7714):
Ben Shuang,Tai Jun,Ma Han,et al.Cilia-Inspired Flexible Arrays for Intelligent Transport of Viscoelastic Microspheres[J].ADVANCED FUNCTIONAL MATERIALS.2018,28(16):-.doi:10.1002/adfm.201706666.
APA:
Ben, Shuang,Tai, Jun,Ma, Han,Peng, Yun,Zhang, Yuan...&Jiang, Lei.(2018).Cilia-Inspired Flexible Arrays for Intelligent Transport of Viscoelastic Microspheres.ADVANCED FUNCTIONAL MATERIALS,28,(16)
MLA:
Ben, Shuang,et al."Cilia-Inspired Flexible Arrays for Intelligent Transport of Viscoelastic Microspheres".ADVANCED FUNCTIONAL MATERIALS 28..16(2018):-