机构：[1]Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China[2]Laboratory of Nutrition, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China临床科室科研平台职能科室临床流行病与循证医学中心临床营养科儿科研究所首都医科大学附属北京儿童医院[3]Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China[4]Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, China[5]CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China
The NLRP3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, Alzheimer's disease and atherosclerosis. Recently, various G protein-coupled receptors (GPCRs) have been reported to be involved in the activation and regulation of the NLRP3 inflammasome by sensing multiple ions, metabolites, and neurotransmitters, suggesting GPCR signaling is an important regulator for NLRP3 inflammasome. Here, we will review how various GPCRs promote or inhibit NLRP3 inflammasome activation and discuss the implications of GPCRs as drug targets for the therapy of NLRP3-driven diseases.
基金：
National Key R&D program of China [2018YFA0507403]; NSFCNational Natural Science Foundation of China [31770991, 91742202, 81525013, 81722022, 81788101]; Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDB29030000]; Young Talent Support Program; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities
第一作者机构：[1]Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China[2]Laboratory of Nutrition, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China
共同第一作者：
通讯作者：
通讯机构：[1]Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China[3]Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China[4]Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, China[5]CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China
推荐引用方式(GB/T 7714)：
Tang Tiantian,Gong Tao,Jiang Wei,et al.GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics[J].TRENDS IN PHARMACOLOGICAL SCIENCES.2018,39(9):798-811.doi:10.1016/j.tips.2018.07.002.
APA：
Tang, Tiantian,Gong, Tao,Jiang, Wei&Zhou, Rongbin.(2018).GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.TRENDS IN PHARMACOLOGICAL SCIENCES,39,(9)
MLA：
Tang, Tiantian,et al."GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics".TRENDS IN PHARMACOLOGICAL SCIENCES 39..9(2018):798-811
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医学