Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility. On Escherichia coli-or Pseudomonas aeruginosa-infected full-thickness skin wounds on rats, the BC-Au-DAPT nanocomposites inhibit bacterial growth and promote wound repair. Thus, the BC-Au-DAPT nanocomposite system is a promising platform for treating superbug-infected wounds.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China [21574050, 31270150, 81361140345, 31470911, 81673039, 51373043]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7164256]; "Strategic Priority Research Program" of the Chinese Academy of SciencesChinese Academy of Sciences [XDA09030305, XDA09030307]; CAS/SAFEA International Partnership Program for Creative Research TeamsChinese Academy of Sciences
第一作者机构：[1]Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China;[2]Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China;[2]Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;[4]Univ Chinese Acad Sci, Beijing 100190, Peoples R China
推荐引用方式(GB/T 7714)：
Li Ying,Tian Yue,Zheng Wenshu,et al.Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds[J].SMALL.2017,13(27):-.doi:10.1002/smll.201700130.
APA：
Li, Ying,Tian, Yue,Zheng, Wenshu,Feng, Yan,Huang, Rong...&Jiang, Xingyu.(2017).Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds.SMALL,13,(27)
MLA：
Li, Ying,et al."Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds".SMALL 13..27(2017):-
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