We investigated the genetic structure of 99 isolates of serotype 23F Streptococcus pneumoniae from children with acute respiratory infections collected over two periods from 1997 to 2006, and 2010. All isolates were susceptible to vancomycin and amoxicillin-clavulanic acid; 97 were resistant to erythromycin, 95 of which carried the ermB gene and two carried both mefA/E and ermB genes. Multidrug resistance to three or more classes of antibiotics was exhibited by 90 isolates. Sequence types ST342 and ST81 were the most frequent in 1997-2006 and 2010, respectively. All CC81 isolates were non-susceptible to beta-lactam antibiotics and had higher minimum inhibitory concentration values for penicillin than other clone complexes and sequence types. The increased beta-lactam antibiotic resistance may have resulted from the replacement of multidrug-resistant clones related to ST81. Long-term studies on S. pneumoniae serotype 23F, especially the ST81 clone, should be conducted to better understand the epidemiological picture of this pathogen in China.
基金：
Special fund for high-level personnel development in the Beijing Health System [2011-3-052]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [2008B64]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Key Lab Major Dis Children, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Natl Key Discipline Pediat, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, 56 Nan Lishi Rd, Beijing 100045, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Key Lab Major Dis Children, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Natl Key Discipline Pediat, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, 56 Nan Lishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Ma X.,Yao K. H.,Yu S. J.,et al.Genotype replacement within serotype 23F Streptococcus pneumoniae in Beijing, China: characterization of serotype 23F[J].EPIDEMIOLOGY AND INFECTION.2013,141(8):1690-1696.doi:10.1017/S0950268812002269.
APA：
Ma, X.,Yao, K. H.,Yu, S. J.,Zhou, L.,Li, Q. H....&Yang, Y. H..(2013).Genotype replacement within serotype 23F Streptococcus pneumoniae in Beijing, China: characterization of serotype 23F.EPIDEMIOLOGY AND INFECTION,141,(8)
MLA：
Ma, X.,et al."Genotype replacement within serotype 23F Streptococcus pneumoniae in Beijing, China: characterization of serotype 23F".EPIDEMIOLOGY AND INFECTION 141..8(2013):1690-1696
