机构：[1]301 Hosp, Dept Pediat, Chinese PLA Gen Hosp, Beijing 100852, Peoples R China;[2]Capital Med Univ, Dept Pediat, Beijing Tian Tan Hosp, Beijing 100050, Peoples R China;[3]Qingdao Univ, Dept Pediat, Affiliated Hosp, Coll Med, Qingdao 266003, Peoples R China;[4]Capital Med Univ, Dept Neurol, Beijing Tian Tan Hosp, Beijing 100050, Peoples R China
Infantile spasms (IS) is a devastating epilepsy syndrome treated with adrenocorticotropic hormone (ACTH). To demonstrate the effects of adrenal dysfunction, adrenalectomy (ADX) and N-methyl-D-aspartate (NMDA)-induced rat model studies of IS were performed. The latency of the seizure in the ADX group decreased and the severity of seizures increased significantly. Hippocampal corticotropin-releasing hormone (CRH) mRNA was overexpressed in ADX rats. After ACTH administration, the latency increased and the severity of seizures decreased significantly. ADX increased seizure susceptibility of the rats to NMDA. Pretreatment with a single high dose of ACTH caused an obvious reduction in susceptibility to NMDA-induced seizures and suppressed CRH mRNA expression. These findings are especially useful for IS patients with adrenal diseases and worthy of further clinical study. (C) 2012 Elsevier B.V. All rights reserved.
基金：
Major State Basic Research Development Program (973)National Basic Research Program of China [2012CB517904]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30770747, 30801249, 81071036]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7081002, 7042024]; Capital Development Foundation of Beijing [2003-2037]; Hygiene Industry-specific Research Projects of China [200802074]
第一作者机构：[1]301 Hosp, Dept Pediat, Chinese PLA Gen Hosp, Beijing 100852, Peoples R China;[2]Capital Med Univ, Dept Pediat, Beijing Tian Tan Hosp, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]301 Hosp, Dept Pediat, Chinese PLA Gen Hosp, Beijing 100852, Peoples R China;
推荐引用方式(GB/T 7714)：
Wang Ya-Jie,Zhang Ying,Liang Xian-Hong,et al.Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats[J].EPILEPSY RESEARCH.2012,100(1-2):125-131.doi:10.1016/j.eplepsyres.2012.02.001.
APA：
Wang, Ya-Jie,Zhang, Ying,Liang, Xian-Hong,Yang, Guang&Zou, Li-Ping.(2012).Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats.EPILEPSY RESEARCH,100,(1-2)
MLA：
Wang, Ya-Jie,et al."Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats".EPILEPSY RESEARCH 100..1-2(2012):125-131
