Maternal immunoglobulin G (IgG) was derived from Wistar rats that just delivered the new offsprings. We examined the effect of this maternal IgG on infantile spasms induced by N-methyl-D-aspartate (NMDA) in immature rats. Pup animals were treated subcutaneously with 10 mg/kg/day maternal IgG from day 11 to day 15 after birth followed by a single intraperitoneal dose of NMDA (15 mg/kg). Administration of maternal IgG decreased the severity and increased the number of ACTH immunoreactive cells in the cortex of rats with NMDA-induced spasms. Furthermore, maternal IgG inhibited NMDA-induced intracellular LDH activity in cultured hippocampal neurons in a dose-dependent manner. The results indicate that maternal IgG can attenuate NMDA-induced seizures. In infantile spasms, some factors may during pregnancy negatively affect the transfer of maternal IgG from mother to fetus thereby causing a decrease in the amount of protective maternal IgG. (c) 2006 Published by Elsevier B.V.
基金：
This research project was sponsored by the National Science Foundation of Beijing (7042024), and the Capital Development Foundation of Beijing (2003–2037).
第一作者机构：[1]Capital Univ Med Sci, Beijing Childrens Hosp, Dept Neurol, Beijing 100045, Peoples R China;[2]Yale Univ, Dept Behav Neurosci, New Haven, CT 06520 USA;[3]Univ Rostock, Dept Neurol, D-2500 Rostock, Germany
通讯作者：
通讯机构：[1]Capital Univ Med Sci, Beijing Childrens Hosp, Dept Neurol, Beijing 100045, Peoples R China;[2]Yale Univ, Dept Behav Neurosci, New Haven, CT 06520 USA;[3]Univ Rostock, Dept Neurol, D-2500 Rostock, Germany
推荐引用方式(GB/T 7714)：
Zou Li-Ping,Zhang Wei-Hua,Wang Hong-Mei,et al.Maternal IgG suppresses NMDA-induced spasms in infant rats and inhibits NMDA-mediated neurotoxicity in hippocampal neurons[J].JOURNAL OF NEUROIMMUNOLOGY.2006,181(1-2):106-111.doi:10.1016/j.jneuroim.2006.08.014.
APA：
Zou, Li-Ping,Zhang, Wei-Hua,Wang, Hong-Mei,Zen, Min,Chen, Kesi&Mix, Eilhard.(2006).Maternal IgG suppresses NMDA-induced spasms in infant rats and inhibits NMDA-mediated neurotoxicity in hippocampal neurons.JOURNAL OF NEUROIMMUNOLOGY,181,(1-2)
MLA：
Zou, Li-Ping,et al."Maternal IgG suppresses NMDA-induced spasms in infant rats and inhibits NMDA-mediated neurotoxicity in hippocampal neurons".JOURNAL OF NEUROIMMUNOLOGY 181..1-2(2006):106-111
