Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women
机构：[1]Nanchang Univ, Jiangxi OAI Joint Res Inst, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China;[2]Natl Inst Control Pharmaceut & Biol Products, Beijing 100050, Peoples R China;[3]Beijing Tiantan Hosp, Beijing 100050, Peoples R China;首都医科大学附属天坛医院[4]Acad Mil Med Sci, Inst Dis Control & Prevent, Beijing 100071, Peoples R China
Objective To investigate the indigenous lactobacilli from the vagina of pregnant women and to screen the isolates with antagonistic potential against pathogenic microorganisms. Methods The strains were isolated from pregnant women's vagina and identified using the API50CH system. The ability of the isolates to produce hydrogen peroxide was analyzed, semi-quantitatively, using the TMB-HRP-MRS agar. The antagonistic effects of the isolates on pathogenic microorganisms were determined with a double layer agar plate. Results One hundred and three lactobacilli strains were isolated from 60 samples of vaginal secretion from healthy pregnant women. Among them, 78 strains could produce hydrogen peroxide, in which 68%, 80%, 80%, and 89% had antagonistic effects against Candida albicans CMCC98001, Staphylococcus aureus CMCC26003, Escherichia coli CMCC44113. and Pseudomonas aeruginosa CMCC10110, respectively. Conclusion The recovery of hydrogen peroxide-producing lactobacilli decreases with the increasing pregnant age and time. The most commonly isolated species from vagina of Chinese pregnant women are Lactobacillus acidophilus and Lactobacillus crispatus. Most of L. acidophilus and L. crispatus produce a high H2O2 level.
基金：
China Scholarship CouncilChina Scholarship Council [2003836007]; 863 program of China [2008AA10Z337]; 973 Program of ChinaNational Basic Research Program of China [2005DKA21202-1]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2007]版：
大类|4 区环境科学与生态学
最新[2023]版：
大类|3 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2006]版：
Q3ENVIRONMENTAL SCIENCESQ4PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Nanchang Univ, Jiangxi OAI Joint Res Inst, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China;[2]Natl Inst Control Pharmaceut & Biol Products, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Nanchang Univ, Jiangxi OAI Joint Res Inst, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China;
推荐引用方式(GB/T 7714)：
XU Heng-Yi,Tian Wan-Hong,Wan Cui-Xiang,et al.Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women[J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES.2008,21(5):365-371.doi:10.1016/S0895-3988(08)60056-2.
APA：
XU, Heng-Yi,Tian, Wan-Hong,Wan, Cui-Xiang,Jia, Li-Jun,Wang, Lan-Yin...&Wei, Hua.(2008).Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,21,(5)
MLA：
XU, Heng-Yi,et al."Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 21..5(2008):365-371
