机构：[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[2]College of Acupuncture and Massage, Beijing University of Chinese Medicine, Beijing, China,[3]Hopital Cardiologique Haut Leveque, Lyric Institute, Université de Bordeaux, Bordeaux-Pessac, France,[4]Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan,[5]Lankenau Institute for Medical Research, Wynnewood, PA, United States,[6]Beijing Anzhen Hospital, Capital Medical University, Beijing, China,首都医科大学附属安贞医院[7]The Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China,[8]Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China,[9]Lankenau Institute for Medical Research and Jefferson Medical College, Philadelphia, PA, United States,[10]Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, China,[11]Hubei Key Laboratory of Cardiology, Wuhan, China
Aims: Risk stratification of patients with Brugada syndrome (BrS) is vital for accurate prognosis and therapeutic decisions. Spontaneous Type 1 ST segment elevation is generally considered to be an independent risk factor for arrhythmic events. Other risk factors include gender, syncope, sudden cardiac arrest (SCA), and positive electrophysiological study (EPS). However, the further risk stratification of spontaneous type 1 combined with the other risk factors remains unclear. The present study pooled data from 4 large trials aiming to systematically evaluate the risk of spontaneous Type-1 ECG when combined with one or more of these other recognized risk factors. Methods: We searched for related studies published from November 2, 2002 to February 10, 2018 in PubMed, EMBASE, Cochrane Library, MEDLINE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Databases. The pooled data were evaluated combining each risk factor with the presence of a spontaneous Type-1 ECG. All analyses were performed using Review Manager, version 5.0.12. Results: Four eligible studies involving 1,338 patients (85% males, mean age: 48.1 +/- 18.1 years) were enrolled. Spontaneous Type-1 ECG was associated with higher risk for ventricular tachycardia/fibrillation (VT/VF) than cases with non-Type 1 ECG in males (odds ratio: 95% CI: 1.84-5.17; P < 0.0001), but not in females (P = 0.29). Among spontaneous Type-1 cases with syncope or with positive EPS, the difference was not statistically significant (P = 0.06 and 0.07, respectively). Patients with Type-1 ECGs and positive EPS were at higher risk than those with negative EPS (95% CI: 1.10-5.04; P = 0.03). Pooled analysis showed an association of Spontaneous Type-1 ECG, Type-1 ECGs combined with male, and Type-1 ECGs combined with positive EPS between increased risk of arrhythmic events. Conclusion: Our results indicate that in BrS patients, a spontaneous Type-1 ECG is an independent risk factor for SCD in males, but not in females. A spontaneous Type-1 BrS is associated with a worse prognosis when combined with positive EPS.
基金：
National Natural Science Foundation Project of ChinaNational Natural Science Foundation of China [81373835, 81430098, 81670304]; National high-level talent special support plan [W02020052]; National clinical research base of TCM project of the State Administration of traditional Chinese medicine [JDZX2015007]; National Heart Lung and Blood Institute of the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [HL47678]
第一作者机构：[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[2]College of Acupuncture and Massage, Beijing University of Chinese Medicine, Beijing, China,
通讯作者：
通讯机构：[1]Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China,[10]Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, China,[11]Hubei Key Laboratory of Cardiology, Wuhan, China
推荐引用方式(GB/T 7714)：
Xinye Li,Frédéric Sacher,Kengo F. Kusano,et al.Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS[J].FRONTIERS IN PHYSIOLOGY.2019,9(JAN):-.doi:10.3389/fphys.2018.01951.
APA：
Xinye Li,Frédéric Sacher,Kengo F. Kusano,Hector Barajas-Martinez,Nian Liu...&Yanwei Xing.(2019).Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS.FRONTIERS IN PHYSIOLOGY,9,(JAN)
MLA：
Xinye Li,et al."Pooled Analysis of Risk Stratification of Spontaneous Type 1 Brugada ECG: Focus on the Influence of Gender and EPS".FRONTIERS IN PHYSIOLOGY 9..JAN(2019):-
