机构：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China[2]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China[3]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, People’s Republic of China[4]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, People’s Republic of China临床科室麻醉中心首都医科大学附属安贞医院[5]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, People’s Republic of China
A multifunctional nanoprobe is described for dual sensing of acidic pH values and glutathione (GSH) by combining the pH-responsive fluorescent probe 3-acetyl-7-hydroxy-2H-chromen-2-one (AHC) and MnO2 nanosheets. The fluorescence of the MnO2/AHC composite is weak due to an inner filter effect. If, however, the MnO2 nanosheets are reductively decomposed by GSH, the blue fluorescence of the pH probe AHC (with excitation/emission maximum at 417/456nm) will be restored. The MnO2 nanosheets also are decomposed by acidic pH values, and the fluorescence of AHC is decreased. According to absorbance and fluorescence signal changes, the pH and GSH induced responses can be easily distinguished. Thus, the nanoprobe can be used for logical analysis of acidic pH values and GSH. The nanoprobe works in the pH range from 4 to 7, and GSH can be determined in the concentration range from 0.5 to 200 mu M.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21705022, 61875141]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M642557]; Joint Funds for the Innovation of Science and Technology of Fujian Province [2017Y9115]; Startup Fund of Mengchao Hepatobiliary Hospital of Fujian Medical University [QDZJ-2014-007]
第一作者机构：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China[2]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China[5]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, People’s Republic of China
推荐引用方式(GB/T 7714)：
Fu Lei,Du Yanlin,Zhang Zhenxi,et al.Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe[J].MICROCHIMICA ACTA.2019,186(8):-.doi:10.1007/s00604-019-3590-7.
APA：
Fu, Lei,Du, Yanlin,Zhang, Zhenxi,Sun, Haiyan,Zheng, Aixian&Liu, Xiaolong.(2019).Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe.MICROCHIMICA ACTA,186,(8)
MLA：
Fu, Lei,et al."Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe".MICROCHIMICA ACTA 186..8(2019):-
