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Water-soluble organic probe for pH sensing and imaging

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收录情况： ◇ SCIE ◇ EI

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机构： [a]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China [b]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China [c]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China [d]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China [e]Fifth People's Hospital, Ganzhou City, Jiangxi Province, China

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关键词： Fluorescence imaging Intramolecular charge transfer pH sensing Phenol group

摘要：

pH value is one of the most important parameters, which show significant application in environmental monitoring, chemistry and biology. Abnormal pH values always associate with some serious diseases, including cancer and Alzheimer's disease. Thus, development of highly sensitive and selective method for pH sensing and imaging is of great importance. In this paper, we synthesized a water-soluble organic probe for pH sensing either through its absorption or through its fluorescent signals. The probe was synthesized from the intermediate containing a phenol group, and the reaction was carried out in concentrated H2SO4 at 90 °C. In this way, the probe can introduce a sulfonic acid group into its structure, and thus improve its water solubility. The synthesized probe is pH-responsive, and the response process is reversible, because that the phenol group in the probe can transfer to deprotonation state with increasing the pH values to improve the intramolecular charge transfer. Meanwhile, the synthesized probe also showed high specificity and excellent biocompatibility, which is suitable for cell imaging applications. © 2019 Elsevier B.V.

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出版当年[2018]版：

大类 | 2 区化学

小类 | 2 区分析化学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区分析化学

JCR分区：

出版当年[2017]版：

Q1 CHEMISTRY, ANALYTICAL

最新[2023]版：

Q1 CHEMISTRY, ANALYTICAL

影响因子： 5.6 最新[2023版] 5.1 最新五年平均 4.244 出版当年[2017版] 3.937 出版当年五年平均 4.162 出版前一年[2016版] 4.916 出版后一年[2018版]

第一作者：

第一作者机构： [a]The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China

通讯作者：

通讯机构： [b]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China [c]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China [d]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China [*1]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, PR China. [*2]Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, PR China.

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Water-soluble organic probe for pH sensing and imaging

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