机构：[1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology ＆ Visual Sciences Key Laboratory,Beijing 100005，China,首都医科大学附属同仁医院[2]Department of ophthalmology,Beijing Anzhen Hospital,Capital Medical University,Bijing 100029,China临床科室眼科首都医科大学附属安贞医院
Glaucoma is the leading cause of irreversible blindness worldwide. The reconstruction of aqueous outflow drainage (RAOD) has recently been proposed to aid in restoring aqueous outflow drainage in primary open-angle glaucoma. However, the mechanism of RAOD remains to be fully understood. Based on literature review and research studies, the potential mechanisms of RAOD are the following: (i) Circumferential dilation of the Schlemm's canal (SC) and surrounding collector channels. (ii) Instant formation of microcracks through RAOD procedures. (iii) Formation of more pores, and local detachment between the SC endothelium (SCE) and basement membrane. (iv) Activation of stem cells by constant mechanical stress caused by the tensional suture placed at the anterior part of the SC. (v) Reversal of trabecular meshwork (TM) herniation. (vi) Mobilization of the reserve of the aqueous drainage. (vii) Change of SCE phenotype. (viii) Mechanosensing and mechanotransducing of TM.
基金：
Beijing Scholar Program; Capital Clinical Characteristics Research Project [Z161100000516081]
第一作者机构：[1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology ＆ Visual Sciences Key Laboratory,Beijing 100005，China,[2]Department of ophthalmology,Beijing Anzhen Hospital,Capital Medical University,Bijing 100029,China
通讯作者：
通讯机构：[1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology ＆ Visual Sciences Key Laboratory,Beijing 100005，China,
推荐引用方式(GB/T 7714)：
Chen Xin,Ning Tian,Meng Li,et al.Mechanism of the reconstruction of aqueous outflow drainage[J].SCIENCE CHINA-LIFE SCIENCES.2018,61(5):534-540.doi:10.1007/s11427-017-9140-8.
APA：
Chen Xin,Ning Tian,Meng Li,Huaizhou Wang&Ningli Wang.(2018).Mechanism of the reconstruction of aqueous outflow drainage.SCIENCE CHINA-LIFE SCIENCES,61,(5)
MLA：
Chen Xin,et al."Mechanism of the reconstruction of aqueous outflow drainage".SCIENCE CHINA-LIFE SCIENCES 61..5(2018):534-540
