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Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs

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资源类型：

收录情况： ◇ SCIE

作者：
Su, Yingying[1] * ; Fan, Zhipeng[2] ; Wu, Xiaoshan[1] ; Li, Yang[1] ; Wang, Fu[1] ; Zhang, Chunmei[1] ; Wang, Jinsong[1,3] ; Du, Jie[4] ; Wang, Songlin[1,3] ;
机构： [1]Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Mol Lab Gene Therapy & Tooth Regenerat, Tian Tan Xi Li 4, Beijing 100050, Peoples R China; [2]Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Lab Mol Signaling & Stem Cells Therapy, Tian Tan Xi Li 4, Beijing 100050, Peoples R China; [3]Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, You An Men Wai Xi Tou Tiao 10, Beijing 100069, Peoples R China; [4]Capital Med Univ, Sch Basic Med Sci, Beijing An Zhen Hosp,Dept Physiol & Pathophysiol, Key Lab Remodeling Related Cardiovasc Dis, You An Men Wai Xi Tou Tiao 10, Beijing 100069, Peoples R China
出处：
DOI： 10.1186/s12864-016-2485-9
ISSN：

关键词： DNA methylation MeDIP-seq Odontogenesis Biomineralization Miniature pig

摘要：
Background: DNA methylation is an important epigenetic modification critical to the regulation of gene expression during development. To date, little is known about the role of DNA methylation in tooth development in large animal models. Thus, we carried out a comparative genomic analysis of genome-wide DNA methylation profiles in E50 and E60 tooth germ from miniature pigs using methylated DNA immunoprecipitation-sequencing (MeDIP-seq). Results: We observed different DNA methylation patterns during the different developmental stages of pig tooth germ. A total of 2469 differentially methylated genes were identified. Functional analysis identified several signaling pathways and 104 genes that may be potential key regulators of pig tooth development from E50 to E60. Conclusions: The present study provided a comprehensive analysis of the global DNA methylation pattern of tooth germ in miniature pigs and identified candidate genes that potentially regulate tooth development from E50 to E60.

基金：
Beijing Municipality Government (Beijing Scholar Program) [PXM 2013_014226_000055, PXM2015_014226_000116, PXM2015_014226_000055, PXM2015_014226_000052, PXM2014_014226_000048, PXM2014_014226_000013, PXM2014_014226_000053, Z121100005212004, PXM 2013_014226_000021, PXM 2013_014226_07_000080, TJSHG201310025005]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 生物
小类 | 2 区 生物工程与应用微生物 3 区 遗传学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生物工程与应用微生物 2 区 遗传学
JCR分区：
出版当年[2014]版：
Q1 GENETICS & HEREDITY Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版：
Q2 GENETICS & HEREDITY Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Mol Lab Gene Therapy & Tooth Regenerat, Tian Tan Xi Li 4, Beijing 100050, Peoples R China;
通讯作者：
通讯机构： [1]Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Mol Lab Gene Therapy & Tooth Regenerat, Tian Tan Xi Li 4, Beijing 100050, Peoples R China; [3]Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, You An Men Wai Xi Tou Tiao 10, Beijing 100069, Peoples R China; [4]Capital Med Univ, Sch Basic Med Sci, Beijing An Zhen Hosp,Dept Physiol & Pathophysiol, Key Lab Remodeling Related Cardiovasc Dis, You An Men Wai Xi Tou Tiao 10, Beijing 100069, Peoples R China
推荐引用方式(GB/T 7714)：
Su Yingying,Fan Zhipeng,Wu Xiaoshan,et al.Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs[J].BMC GENOMICS.2016,17(1):-.doi:10.1186/s12864-016-2485-9.
APA：
Su, Yingying,Fan, Zhipeng,Wu, Xiaoshan,Li, Yang,Wang, Fu...&Wang, Songlin.(2016).Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs.BMC GENOMICS,17,(1)
MLA：
Su, Yingying,et al."Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs".BMC GENOMICS 17..1(2016):-

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