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Urinary Proteins with Post-translational Modifications

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机构: [1]Chinese Acad Med Sci, Inst Basic Med Sci, Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, Beijing 100730, Peoples R China; [2]Capital Med Univ, Beijing Anzhen Hosp, Dept Nephrol, Beijing, Peoples R China; [3]Peking Union Med Coll Hosp, Dept Nephrol, Beijing, Peoples R China; [4]Chinese Acad Med Sci, Inst Basic Med Sci, Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, 5 Dong Dan San Tiao, Beijing 100730, Peoples R China
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关键词: Posttranslational modification Urine proteome Unenriched

摘要:
Research on the human urine proteome may lay the foundation for the discovery of relevant disease biomarkers. Posttranslational modifications (PTMs) have important effects on the functions of protein biomarkers. Identifying PTMs without enrichment adds no extra steps to conventional identification procedures for urine proteomics. The only difference is that this method requires software that can conduct unrestrictive identifications of PTMs. These PTMs include methylation, dehydration, oxidation, hydroxylation, phosphorylation, or dihydroxylation. These data are useful reference for PTM biomarker discovery in the future.

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出版当年[2014]版:
大类 | 4 区 医学
小类 | 4 区 生物学 4 区 医学:研究与实验
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出版当年[2013]版:
Q2 BIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL
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影响因子: 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者:
第一作者机构: [1]Chinese Acad Med Sci, Inst Basic Med Sci, Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, Beijing 100730, Peoples R China;
通讯作者:
通讯机构: [1]Chinese Acad Med Sci, Inst Basic Med Sci, Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, Beijing 100730, Peoples R China; [4]Chinese Acad Med Sci, Inst Basic Med Sci, Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, 5 Dong Dan San Tiao, Beijing 100730, Peoples R China
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