Magnetic resonance elastography (MRE) is a noninvasive phase-contrast technique for estimating the mechanical properties of tissues by imaging propagating mechanical waves within the tissue. In this study, we hypothesize that changes in arterial wall stiffness, experimentally induced by formalin fixation, can be measured using MRE in ex vivo porcine aortas. In agreement with our hypothesis, the significant stiffness increase after sample fixation was clearly demonstrated by MRE and confirmed by mechanical testing. The results indicate that MRE can be used to examine the stiffness changes of the aorta. This study has provided evidence of the effectiveness of using MRE to directly assess the stiffness change in aortic wall. The results offer motivation to pursue MRE as a noninvasive method for the evaluation of arterial wall mechanical properties. (C) 2012 Elsevier Inc. All rights reserved.
基金：
National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [EB001981]; Natural Science Foundation of ChinaNational Natural Science Foundation of China [81041013]; Chinese Ministry of Science and TechnologyMinistry of Science and Technology, China [2010DFB30040]; Program for Excellent Talents from Beijing city
Xu Lei,Chen Jun,Yin Meng,et al.Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography[J].MAGNETIC RESONANCE IMAGING.2012,30(1):122-127.doi:10.1016/j.mri.2011.09.009.
APA：
Xu, Lei,Chen, Jun,Yin, Meng,Glaser, Kevin J.,Chen, Qingshan...&Ehman, Richard L..(2012).Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography.MAGNETIC RESONANCE IMAGING,30,(1)
MLA：
Xu, Lei,et al."Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography".MAGNETIC RESONANCE IMAGING 30..1(2012):122-127
