APOLIPOPROTEIN E POLYMORPHISM AND FRAILTY: APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH FATIGUE BUT NOT FRAILTY SYNDROME IN A COMMUNITY-DWELLING OLDER POPULATION COHORT
机构：[1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China神经科系统内科系统神经内科老年医学科首都医科大学宣武医院[2]National Clinical Research Center for Geriatric Disorders, Beijing, China[3]Chinese National Human Genome Center, Beijing, China[4]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China[5]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing, China[6]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Objective: Frailty is known to be influenced by genetics, however, little evidence on the association of Apolipoprotein E (ApoE) genotype and frailty exists which we aim to investigate. Design This study is a cross-sectional analysis from a prospective longitudinal study cohort. Setting and Participants: Community-dwelling individuals aged 55 years and older from Beijing region in China. Measurements: A total of 3,569 older adults with a mean age of 75.06(+/- 6.79) years were included. We investigated the association between ApoE polymorphism and frailty syndrome using the frailty index (FI) and frailty phenotype (including association with individual components of the frailty phenotype). Logistic regressions were performed to investigate the relation between ApoE variants and frailty. Results There was no significant association between ApoE variants and frailty as assessed by the FI. In the age and sex-adjusted model, compared to the ApoE e3/e3 carriers ApoE e4 carriers had almost 1.5 times higher odds of being frail as assessed by the frailty phenotype. However, the significance was lost on the model with adjustment for cognitive impairment. Compared to the ApoE e3/e3 carriers ApoE e4 carriers had almost two times higher odds of fatigue. ApoE e4 heterozygotes had higher odds of fatigue compared to ApoE e4 non-carriers. No significant association was found between ApoE variants and other components of frailty phenotype. Conclusions: Our findings do not support an association between ApoE genotype and frailty irrespective of the frailty assessment tools. Fatigue in older adults is the only component of frailty phenotype influenced by ApoE genotype.
基金：
National Key R&D Program of China [2018YFC1312001]; Beijing Municipal Commission on Science and Technology [D07050701130000, 070S0701130701]
第一作者机构：[1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China[2]National Clinical Research Center for Geriatric Disorders, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China,
推荐引用方式(GB/T 7714)：
Chhetri J. K.,Ma L.,Zheng Z.,et al.APOLIPOPROTEIN E POLYMORPHISM AND FRAILTY: APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH FATIGUE BUT NOT FRAILTY SYNDROME IN A COMMUNITY-DWELLING OLDER POPULATION COHORT[J].JOURNAL OF NUTRITION HEALTH & AGING.2021,25(4):410-415.doi:10.1007/s12603-020-1522-1.
APA：
Chhetri, J. K.,Ma, L.,Zheng, Z.,Liu, F. -Y.,Zhao, J....&Chan, P..(2021).APOLIPOPROTEIN E POLYMORPHISM AND FRAILTY: APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH FATIGUE BUT NOT FRAILTY SYNDROME IN A COMMUNITY-DWELLING OLDER POPULATION COHORT.JOURNAL OF NUTRITION HEALTH & AGING,25,(4)
MLA：
Chhetri, J. K.,et al."APOLIPOPROTEIN E POLYMORPHISM AND FRAILTY: APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH FATIGUE BUT NOT FRAILTY SYNDROME IN A COMMUNITY-DWELLING OLDER POPULATION COHORT".JOURNAL OF NUTRITION HEALTH & AGING 25..4(2021):410-415
