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Anti-contactin-associated protein-like 2 antibody-associated cerebellar ataxia: A case report and literature review

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机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
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关键词: Autoimmune encephalitis Cerebellar ataxia Contactin associated protein-like 2

摘要:
The spectrum of anti-contactin-associated protein-like 2 (CASPR2) antibody-associated disease is expanding and the involvement of cerebellum was reported in the past few years. We report a 45-year-old male with chronically progressive cerebellar ataxia. CASPR2 antibodies were detected in his serum and cerebellar atrophy was observed on MRI. His symptoms improved prominently with steroids and intravenous immunoglobulins. 23 cases with CASPR2 antibodies and cerebellar ataxia were identified from previous publications. Most of patients showed acute or subacute onset with other typical presentations of anti-CASPR2 antibody-associated disease, such as limbic encephalitis. Immunotherapy was effective in the majority of patients. © 2021

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出版当年[2020]版:
大类 | 3 区 医学
小类 | 4 区 免疫学 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
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出版当年[2019]版:
Q2 NEUROSCIENCES Q3 IMMUNOLOGY
最新[2023]版:
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

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第一作者机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
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