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Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

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机构： [a]Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China [b]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China [c]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [d]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China [e]School of Biomedical Engineering, Dalian University of Technology, Dalian, China [f]Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences, Shanghai, China [g]Biomedical Engineering Institute, Hainan University, Haikou, China [h]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [i]National Clinical Research Center for Geriatric Disorders, Beijing, China [j]Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China [k]McGovern Institute for Brain Research, Peking University, Beijing, China

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关键词： blood oxygen level-dependent (BOLD) cerebral blood flow (CBF) cerebral blood volume (CBV) cerebral metabolic rate of oxygen (CMRO2) Subjective cognitive decline (SCD)

摘要：

Previous studies reported abnormally increased and/or decreased blood oxygen level-dependent (BOLD) activations during functional tasks in subjective cognitive decline (SCD). The neurophysiological basis underlying these functional aberrations remains debated. This study aims to investigate vascular and metabolic responses and their dependence on cognitive processing loads during functional tasks in SCD. Twenty-one SCD and 18 control subjects performed parametric N-back working-memory tasks during MRI scans. Task-evoked percentage changes (denoted as δ) in cerebral blood volume (δCBV), cerebral blood flow (δCBF), BOLD signal (δBOLD) and cerebral metabolic rate of oxygen (δCMRO2) were evaluated. In the frontal lobe, trends of decreased δCBV, δCBF and δCMRO2 and increased δBOLD were observed in SCD compared with control subjects under lower loads, and these trends increased to significant differences under the 3-back load. δCBF was significantly correlated with δCMRO2 in controls, but not in SCD subjects. As N-back loads increased, the differences between SCD and control subjects in δCBF and δCMRO2 tended to enlarge. In the parietal lobe, no significant between-group difference was observed. Our findings suggested that impaired vascular and metabolic responses to functional tasks occurred in the frontal lobe of SCD, which contributed to unusual BOLD hyperactivation and was modulated by cognitive processing loads. © The Author(s) 2021.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢 2 区血液学 2 区神经科学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区内分泌学与代谢 2 区血液学 2 区神经科学

JCR分区：

出版当年[2019]版：

Q1 ENDOCRINOLOGY & METABOLISM Q1 NEUROSCIENCES Q1 HEMATOLOGY

最新[2023]版：

Q1 ENDOCRINOLOGY & METABOLISM Q1 HEMATOLOGY Q1 NEUROSCIENCES

影响因子： 4.9 最新[2023版] 6.1 最新五年平均 5.681 出版当年[2019版] 5.787 出版当年五年平均 6.04 出版前一年[2018版] 6.2 出版后一年[2020版]

第一作者：

第一作者机构： [a]Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China [b]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

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通讯作者：

通讯机构： [*1]Center for MRI Research, Peking University, Beijing 100871, China [*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

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Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

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