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Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion - Current Approaches and Future Directions.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA [2]Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [3]Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls University, T€ubingen, Germany [4]Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA [5]Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany [6]Department of Neurology, Sana Regio Klinikum, Pinneberg, Germany [7]Department of Neurology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA [8]Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA [9]Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA [10]Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [11]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China [12]Department of Radiology, NYU Langone Health, New York City, New York. USA [13]Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [14]Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.

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关键词： Central Retinal Artery Occlusion—Ischemic Stroke—Intravenous Thrombolysis—Ultrasound—Fluorescein Angiography—Optical Coherence Tomography—Photoacoustic Imaging—Ischemic Penumbra

摘要：

Central retinal artery occlusion (CRAO) is a form of acute ischemic stroke which affects the retina. Intravenous thrombolysis is emerging as a compelling therapeutic approach. However, it is not known which patients may benefit from this therapy because there are no imaging modalities that adequately distinguish viable retina from irreversibly infarcted retina. The inner retina receives arterial supply from the central retinal artery and there is robust collateralization between this circulation and the outer retinal circulation, provided by the posterior ciliary circulation. Fundus photography can show canonical changes associated with CRAO including a cherry-red spot, arteriolar boxcarring and retinal pallor. Fluorescein angiography provides 2-dimensional imaging of the retinal circulation and can distinguish a complete from a partial CRAO as well as central versus peripheral retinal non-perfusion. Transorbital ultrasonography may assay flow through the central retinal artery and is useful in the exclusion of other orbital pathology that can mimic CRAO. Optical coherence tomography provides structural information on the different layers of the retina and exploratory work has described its utility in determining the time since onset of ischemia. Two experimental techniques are discussed. 1) Retinal functional imaging permits generation of capillary perfusion maps and can assay retinal oxygenation and blood flow velocity. 2) Photoacoustic imaging combines the principles of optical excitation and ultrasonic detection and - in animal studies - has been used to determine the retinal oxygen metabolic rate. Future techniques to determine retinal viability in clinical practice will require rapid, easily used, and reproducible methods that can be deployed in the emergency setting. Copyright © 2021 Elsevier Inc. All rights reserved.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区神经科学 4 区外周血管病

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学 4 区外周血管病

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出版当年[2019]版：

Q4 PERIPHERAL VASCULAR DISEASE Q4 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE

影响因子： 2 最新[2023版] 2.1 最新五年平均 1.787 出版当年[2019版] 1.825 出版当年五年平均 1.646 出版前一年[2018版] 2.136 出版后一年[2020版]

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第一作者机构： [1]Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA

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Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion - Current Approaches and Future Directions.

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