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Global Fractional Anisotropy: Effect on Resting-state Neural Activity and Brain Networking in Healthy Participants.

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收录情况： ◇ SCIE

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机构： [a]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [b]Department of Radiology (IDI) and Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain [c]Department of Radiology, SDN, Italy [d]Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China [e]Stroke Diagnosis and Monitoring Division, AtheroPointTM, Roseville, CA, USA [f]Department of Neurology, University of Cagliari, Cagliari, Italy

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关键词： global fractional anisotropy limbic system default mode network resting-state fMRI

摘要：

The global fractional anisotropy (gFA) is a structural marker of white matter myelination and integrity. Previous studies already evidenced that aging-related reduced integrity of specific white matter tracts is associated with decreased functional connectivity in several hubs. However, the correlations between gFA and functional brain connectivity remain unknown. In this cross-sectional study, we analyzed structural and functional MR datasets of 79 healthy participants from the Leipzig Study for Mind-Body-Emotion Interactions. DTI model-based method was used to quantify gFA values. We tested associations between gFA, age, and gender. The fractional amplitude of low-frequency fluctuations (fALFF) and ROI-to-ROI connectivity were analyzed in a regression model for evaluating the effects of gFA on brain activity and networking, respectively. A negative correlation was found between gFA and age (ρ = -0.343; p = 0.002). No statistically significant correlation as found between gFA and gender (p = 0.229). Higher values of gFA were associated with increased brain regional activity, including areas of the default mode network. There was a higher degree of correlation between some regions, particularly those that conform to the limbic system. Our study demonstrates that gFA influences regional neural activity and brain networking on resting, particularly the limbic system.Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区神经科学

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出版当年[2019]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 2.9 最新[2023版] 3 最新五年平均 3.056 出版当年[2019版] 3.343 出版当年五年平均 3.244 出版前一年[2018版] 3.59 出版后一年[2020版]

第一作者：

第一作者机构： [a]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [*1]Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, km 4,500, CAP: 09042 Monserrato, Cagliari, Italy.

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通讯作者：

通讯机构： [a]Department of Radiology, AOU Cagliari, University of Cagliari, Italy [*1]Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, km 4,500, CAP: 09042 Monserrato, Cagliari, Italy.

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Global Fractional Anisotropy: Effect on Resting-state Neural Activity and Brain Networking in Healthy Participants.

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