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Animal Models of Epilepsy: A Phenotype-oriented Review

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [4]Clinical Research Center for Epilepsy Capital Medical University, Beijing, China

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关键词： epilepsy animal models seizure phenotype kindling model temporal lobe epilepsy

摘要：

Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious damage to brain function, which is usually observed in patients with temporal lobe epilepsy. Controlling seizure attacks is vital for the treatment and prognosis of epilepsy. Animal models, such as the kindling model, which was the most widely used model in the past, allow the understanding of the potential epileptogenic mechanisms and selection of antiepileptic drugs. In recent years, various animal models of epilepsy have been established to mimic different seizure types, without clear merits and demerits. Accordingly, this review provides a summary of the views mentioned above, aiming to provide a reference for animal model selection.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区老年医学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区老年医学

JCR分区：

出版当年[2020]版：

Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY

影响因子： 7 最新[2023版] 7.1 最新五年平均 6.745 出版当年[2020版] 6.936 出版当年五年平均 5.402 出版前一年[2019版] 9.968 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China [4]Clinical Research Center for Epilepsy Capital Medical University, Beijing, China [*1]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China

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