机构：[1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China[2]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[3]The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[4]School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China[5]Aerospace Medical Center, Aerospace Center Hospital, Beijing, China
Posttraumatic stress disorder (PTSD) is a psychiatric disorder that is associated with long-lasting memories of traumatic experiences. Extinction and discrimination of fear memory have become therapeutic targets for PTSD. Newly developed optogenetics and advanced in vivo imaging techniques have provided unprecedented spatiotemporal tools to characterize the activity, connectivity, and functionality of specific cell types in complicated neuronal circuits. The use of such tools has offered mechanistic insights into the exquisite organization of the circuitry underlying the extinction and discrimination of fear memory. This review focuses on the acquisition of more detailed, comprehensive, and integrated neural circuits to understand how the brain regulates the extinction and discrimination of fear memory. A future challenge is to translate these researches into effective therapeutic treatment for PTSD from the perspective of precise regulation of the neural circuits associated with the extinction and discrimination of fear memories.
基金：
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science
Foundation of China (Grant No. 92049102) and the National
Key Research and Development Program of China (Grant No.
2018YFC1312302-3).
第一作者机构：[1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China[4]School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China[5]Aerospace Medical Center, Aerospace Center Hospital, Beijing, China[*1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, NO.5 Building, Zhongguancun South Street, Beijing, 100081, China.[*2]School of Materials Science and Engineering, Beijing Institute of Technology, No. 5, South Street, Zhongguancun, Haidian District, Beijing, 100081, China
推荐引用方式(GB/T 7714)：
Yan Yan,Aierken Ailikemu,Wang Chunjian,et al.Neuronal Circuits Associated with Fear Memory: Potential Therapeutic Targets for Posttraumatic Stress Disorder.[J].NEUROSCIENTIST.2023,29(3):332-351.doi:10.1177/10738584211069977.
APA：
Yan Yan,Aierken Ailikemu,Wang Chunjian,Jin Wei,Quan Zhenzhen...&Zhao Juan.(2023).Neuronal Circuits Associated with Fear Memory: Potential Therapeutic Targets for Posttraumatic Stress Disorder..NEUROSCIENTIST,29,(3)
MLA：
Yan Yan,et al."Neuronal Circuits Associated with Fear Memory: Potential Therapeutic Targets for Posttraumatic Stress Disorder.".NEUROSCIENTIST 29..3(2023):332-351
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