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Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors.

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机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, People's Republic of China. [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, People's Republic of China. [4]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China. [5]Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China. [6]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. [7]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
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关键词: stem cell rejuvenation regeneration aging

摘要:
Stem cell therapies, including stem cell transplantation and rejuvenation of stem cells in situ, are promising avenues for tackling a broad range of diseases. Stem cells can both self-renew and differentiate into other cell types, and play a significant role in the regulation of tissue homeostasis and regeneration after cell degeneration or injury. However, stem cell exhaustion or dysfunction increases with age and impedes the normal function of multiple tissues and systems. Thus, stem cell therapies could provide a solution to aging and age-associated diseases. Here, we discuss recent advances in understanding the mechanisms that regulate stem cell regeneration. We also summarize potential strategies for rejuvenating stem cells that leverage intrinsic and extrinsic factors. These approaches may pave the way toward therapeutic interventions aiming at extending both health and life span.© The Author(s) 2022. Published by Oxford University Press.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 细胞与组织工程
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞与组织工程
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出版当年[2020]版:
Q1 CELL & TISSUE ENGINEERING
最新[2023]版:
Q1 CELL & TISSUE ENGINEERING

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, People's Republic of China. [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, People's Republic of China.
通讯作者:
通讯机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. [2]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, People's Republic of China. [3]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, People's Republic of China. [4]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China. [6]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China. [7]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. [*1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, People’s Republic of China [*2]Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA, USA [*3]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 3A Datun Road, Chaoyang District, Beijing 100101, People’s Republic of China
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