详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Aberrant topological organization and age-related differences in the human connectome in subjective cognitive decline by using regional morphology from magnetic resonance imaging.

55| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University, Beijing, China [2]Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei, China [3]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China [4]School of Electrical Engineering, Yanshan University, Qinhuangdao, China [5]Measurement Technology and Instrumentation Key Lab of Hebei Province, Qinhuangdao, China [6]School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China [7]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [8]Biomedical Engineering Institute, Hainan University, Haikou, China [9]National Clinical Research Center for Geriatric Disorders, Beijing, China

出处：

DOI：

ISSN：

关键词： Aging Structural MRI Morphological network Graph theory Subjective cognitive decline

摘要：

Subjective cognitive decline (SCD) is characterized by self-experienced deficits in cognitive capacity with normal performance in objective cognitive tests. Previous structural covariance studies showed specific insights into understanding the structural alterations of the brain in neurodegenerative diseases. Moreover, in subjects with neurodegenerative diseases, accelerated brain degeneration with aging was shown. However, the age-related variations in coordinated topological patterns of morphological networks in individuals with SCD remain poorly understood. In this study, 77 individual morphological networks were constructed, including 42 normal controls (NCs) and 35 SCD individuals, from structural magnetic resonance imaging (sMRI). A stepwise linear regression model and partial correlation analysis were constructed to evaluate the differences in age-related alterations of the network properties in individuals with SCD compared with NCs. Compared with NC, the properties of integration and segregation in individuals with SCD were lower, and the aberrant metrics were negatively correlated with age in SCD. The rich-club connections persevered, but the paralimbic system connections were disrupted in individuals with SCD compared with NCs. In addition, age-related differences in nodal global efficiency are distributed mainly in prefrontal cortex regions. In conclusion, the age-related disruption of topological organizations in individuals with SCD may indicate that the degeneration of brain efficiency with aging was accelerated in individuals with SCD.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区

医学

小类 | 1 区解剖学与形态学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 1 区解剖学与形态学 3 区神经科学

JCR分区：

出版当年[2020]版：

Q1 ANATOMY & MORPHOLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q1 ANATOMY & MORPHOLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.9 最新五年平均 3.27 出版当年[2020版] 4.093 出版当年五年平均 3.298 出版前一年[2019版] 3.748 出版后一年[2021版]

第一作者：

第一作者机构： [1]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University, Beijing, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

Aberrant topological organization and age-related differences in the human connectome in subjective cognitive decline by using regional morphology from magnetic resonance imaging.

文献详情

相关文献