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Gas chromatography properties and mass spectrometry fragmentation of anabolic androgenic steroids in doping control

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收录情况： ◇ SCIE

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机构： [1]Guangdong Sports Sci Res Inst, Guangzhou, Peoples R China [2]China Antidoping Agcy, Drug & food Antidoping Lab, Beijing, Peoples R China [3]Beijing Sport Univ, Beijing Antidoping Lab, Beijing, Peoples R China [4]Capital Med Univ, Clin Res Ctr Geriatr Dis 4Nat, Xuanwu Hosp, Beijing, Peoples R China [5]Beijing Narcot Control Technol Ctr, Beijing, Peoples R China [6]Shenzhen Longhua Dist Matern & Child Healthcare Ho, Shenzhen, Peoples R China

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关键词： anabolic androgenic steroids characteristic fragment ions doping control fragmentation pattern GC-MS retention time

摘要：

Aim: This study aimed to investigate the gas chromatographic properties and mass spectrometric fragmentations of anabolic androgenic steroids (AASs) after trimethylsilylated derivatization. Materials & methods: A total of 113 AASs were analyzed through gas chromatography-mass spectrometry in the full-scan mode. Results: New fragmentation pathways yielding m/z 129, 143 and 169 ions were analyzed. Based on the characteristics of the A-ring, seven classes of drugs were identified and analyzed. Conclusion: The fragmentation pathway of a new classification of 4-en-3-hydroxyl was reported for the first time. The relationship between the chemical structures of AASs and their retention time, along with their molecular ion peak abundance, was also reported herein for the first time.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 3 区分析化学 4 区生化研究方法

最新[2023]版：

大类 | 4 区医学

小类 | 4 区生化研究方法 4 区分析化学

JCR分区：

出版当年[2021]版：

Q3 BIOCHEMICAL RESEARCH METHODS Q3 CHEMISTRY, ANALYTICAL

最新[2023]版：

Q3 BIOCHEMICAL RESEARCH METHODS Q3 CHEMISTRY, ANALYTICAL

影响因子： 1.9 最新[2023版] 2.1 最新五年平均 2.695 出版当年[2021版] 2.626 出版当年五年平均 2.681 出版前一年[2020版] 1.8 出版后一年[2022版]

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第一作者机构： [1]Guangdong Sports Sci Res Inst, Guangzhou, Peoples R China [2]China Antidoping Agcy, Drug & food Antidoping Lab, Beijing, Peoples R China

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