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Advances in epileptic network findings of hypothalamic hamartomas

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机构: [1]School of Engineering Medicine, Beihang University, Beijing, China [2]Department of Neurosurgery,Xuanwu Hospital, Capital Medical University, Beijing, China [3]Clinical Research Center for Epilepsy,Capital Medical University, Beijing, China [4]Department of Neurology, Xuanwu Hospital, Capital MedicalUniversity, Beijing, China [5]School of Biological Science and Medical Engineering, Beihang University,Beijing, China [6]Neurology Deparment, CHU Grenoble Alpes, University Grenoble Alpes, GrenobleInstitute Neuroscience, Grenoble, France
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关键词: Hypothalamic hamartomas epileptic network seizure semiology

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Hypothalamic hamartomas (HHs) are congenital developmental malformations located in the hypothalamus. They are associated with a characteristic clinical manifestation known as gelastic seizures (GS). However, the traditional understanding of HHs has been limited, resulting in insufficient treatment options and high recurrence rates of seizures after surgery. This is consistent with the network hypothesis of focal epilepsy that the epileptogenic zone is not only limited to HH but may also involve the distant cerebral cortex external to the HH mass. The epilepsy network theory, on the other hand, provides a new perspective. In this study, we aim to explore HH-related epilepsy as a network disease, challenging the conventional notion of being a focal lesional disease. We analyze various aspects of HHs, including genes and signaling pathways, local circuits, the whole-brain level, phenotypical expression in terms of seizure semiology, and comorbidities. By examining HHs through the lens of network theory, we can enhance our understanding of the condition and potentially identify novel approaches for more effective management and treatment of epilepsy associated with HHs.© The Author(s) 2024.

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Q2 CLINICAL NEUROLOGY

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第一作者机构: [1]School of Engineering Medicine, Beihang University, Beijing, China [*1]School of Engineering Medicine, Beihang University, 37 Xueyuan Road, Beijing 100191, China
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通讯机构: [1]School of Engineering Medicine, Beihang University, Beijing, China [*1]School of Engineering Medicine, Beihang University, 37 Xueyuan Road, Beijing 100191, China
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