Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR regulate the aging program and delay aging in multiple tissues remains unclear. Here, we demonstrated that MET and NR attenuate aging features in human mesenchymal stem cells. Moreover, by systematically investigating the pathophysiological changes in different tissues from aged rats after oral administration of MET and NR, we showed that both MET and NR treatment alleviated various aging-related characteristics in multiple tissues, including inflammation, fibrosis, and protein aggregates. Consistently, MET or NR treatment partially rescued aging-related gene expression changes in aged rats. Collectively, we report that both MET and NR attenuate senescence phenotypes in human stem cells in vitro and in a variety of rodent tissues in vivo, thus providing a valuable resource and foundation for further evaluation of these two compounds against aging.
基金：
National Key Research and Development Program of China; Chinese Academy of Sciences [2018YFC2000100, 2018YFA0107203, 2020YFA0112200, 2021YFF1201005, 2021ZD0202401]; National Key Research and Development Program of China [XDA16000000]; Strategic Priority Research Program of the Chinese Academy of Sciences [YSBR-076, YSBR-012]; CAS Project for Young Scientists in Basic Research [81921006, 82125011, 92149301, 92168201, 91949209, 92049304, 92049116, 32121001, 82192863, 82122024, 82071588, 32100937, 31900524, 81861168034, 82201727]; National Natural Science Foundation of China [Z190019]; Program of the Beijing Natural Science Foundation [GJTD-2019-06, GJTD-2019-08]; K. C. Wong Education Foundation [11000022T000000461062]; Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes [E1CAZW0401]; Youth Innovation Promotion Association of CAS [YESS20200012]; Young Elite Scientists Sponsorship Program by CAST [CAS-WX2021SF-0301, CAS-WX2022SDC-XK14]; Informatization Plan of Chinese Academy of Sciences [2021-1045]; Tencent Foundation [QML20200802]; Beijing Hospitals Authority Youth Programme [2021KF02]; Open Research Program of State Key Laboratory of Membrane Biology [2021-A-001]; Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[1]Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing 100053, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing 100053, Peoples R China[2]Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing 100101, Peoples R China[3]Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing 100101, Peoples R China[4]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China[5]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China[6]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China[7]Univ Chinese Acad Sci, Beijing 100049, Peoples R China[8]Capital Med Univ, Beijing Municipal Geriatr Med Res Ctr, Aging Translat Med Ctr, Int Ctr Aging & Canc,Xuanwu Hosp, Beijing 100053, Peoples R China[9]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China[10]Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China
推荐引用方式(GB/T 7714)：
Geng Lingling,Zhang Bin,Liu Haisong,et al.A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats[J].LIFE MEDICINE.2023,2(1):doi:10.1093/lifemedi/lnac045.
APA：
Geng, Lingling,Zhang, Bin,Liu, Haisong,Wang, Si,Cai, Yusheng...&Zhang, Weiqi.(2023).A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats.LIFE MEDICINE,2,(1)
MLA：
Geng, Lingling,et al."A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats".LIFE MEDICINE 2..1(2023)
