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Functional connectivity changes in two cortico-hippocampal networks of Alzheimer's disease continuum and their correlations with cognition: A SILCODE study

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机构： [1]1Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China. [2]German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. [3]Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany. [4]Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn Medical Center, Bonn, Germany. [5]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China. [6]International Big-Data Center for Depression Research, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [7]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [8]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. [9]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China. [10]Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. [11]State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, Hainan, China. [12]Alliance of Pre AD, National Clinical Research Center for Geriatric Diseases, Beijing, China. [13]Department of Neurology, The Central Hospital of Karamay, Xinjiang, China.

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关键词： Alzheimer’s disease anterior temporal system functional connectivity medial temporal lobes parahippocampal cortex perirhinal cortex posterior medial system retrosplenial cortex subjective cognitive decline

摘要：

The anterior-temporal (AT) and posterior-medial (PM) networks have been proposed to play pivotal roles in the memory processing associated with Alzheimer's disease (AD). Nevertheless, these two networks' intrinsic functional coupling characteristics are still vague in different AD stages.To explore the functional connectivity (FC) alterations within and across the AT&PM networks in patients with dementia of the Alzheimer's type (DAT), mild cognitive impairment (MCI), subjective cognitive decline (SCD), and normal controls (NC).A total of 368 participants over 50 years old from the SILCODE study were recruited, including 99 NC, 134 SCD, 67 MCI, and 68 DAT patients. All the participants underwent a resting-state functional magnetic resonance imaging scan and a battery of neuropsychological tests. The 56 regions-of-interest of the AT&PM networks were defined broadly following existing literature. The FCs were calculated using DPABINet and compared among these four groups. Correlation analyses were performed on FCs and cognitive tests.Analysis of variance of all four groups showed significant alteration, mainly in the PM networks. Compared to NC, globally decreased FCs regarding AT&PM networks were observed in DAT and MCI patients, while globally increased FCs regarding AT&PM networks were observed in SCD. The decreased FCs in DAT were significantly correlated with the neuropsychological test on the memory domain.The FC alteration showed different patterns across the AD continuum, especially in individuals with SCD. The elevated FCs in the AT&PM networks of SCD may implicate certain compensating processes in the early stage of AD.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

第一作者：

第一作者机构： [1]1Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China. [2]German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. [3]Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany. [4]Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn Medical Center, Bonn, Germany.

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通讯作者：

通讯机构： [1]1Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China. [5]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China. [6]International Big-Data Center for Depression Research, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [7]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [8]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. [9]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China. [11]State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, Hainan, China. [12]Alliance of Pre AD, National Clinical Research Center for Geriatric Diseases, Beijing, China. [13]Department of Neurology, The Central Hospital of Karamay, Xinjiang, China.

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Functional connectivity changes in two cortico-hippocampal networks of Alzheimer's disease continuum and their correlations with cognition: A SILCODE study

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