个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xueyan Jiang[1,2,3] * ; Xiaochen Hu[4,*1] * ; Marcel Daamen[2] ; Xiaoqi Wang[1] ; Chunqiu Fan[1] ; Dix Meiberth[2,4] ; Annika Spottke[2,5] ; Sandra Roeske[2] ; Klaus Fliessbach[2,6] ; Eike Jakob Spruth[7,8] ; Slawek Altenstein[7,8] ; Andrea Lohse[8] ; Niels Hansen[9] ; Wenzel Glanz[10] ; Enise I. Incesoy[10,11,12] ; Laura Dobisch[10] ; Daniel Janowitz[13] ; Boris-Stephan Rauchmann[14] ; Alfredo Ramirez[2,6,15,16,17] ; Ingo Kilimann[18,19] ; Matthias H. Munk[20,21] ; Xiao Wang[22] ; Luisa-Sophie Schneider[22] ; Tatjana Gabelin[22] ; Nina Roy[2] ; Steffen Wolfsgruber[2,6] ; Luca Kleineidam[2,6] ; Stefan Hetzer Peter Dechent[23,24] ; Michael Ewers[25] ; Klaus Scheffler[26] ; Holger Amthauer[27] ; Ralph Buchert[27,28] ; Markus Essler[29] ; Alexander Drzezga[2,30,31] ; Axel Rominger[32,33] ; Bernd J. Krause[34] ; Matthias Reimold[35] ; Josef Priller[7,8,36,37] ; Anja Schneider[2,6] ; Jens Wiltfang[9,38,39] ; Katharina Buerger[13,25] ; Robert Perneczky[14,25,40,41] ; Stefan Teipel[18,19] ; Christoph Laske[20,42] ; Oliver Peters[7,22] ; Emrah Düzel[10,11] ; Michael Wagner[2,6] ; Jiehui Jiang[43] ; rank Jessen[2,4,15] ; Henning Boecker[2,44] ; Ying Han[1,3,45,46,*2] ;
机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [2]German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany [3]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [4]Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany. [5]Department of Neurology, University of Bonn, Bonn, Germany. [6]University of Bonn Medical Center, Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn, Germany. [7]German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. [8]Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany [9]Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Goettingen, Germany. [10]German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. [11]Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany. [12]Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, Magdeburg, Germany. [13]Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. [14]Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. [15]Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. [16]Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. [17]Department of Psychiatry &Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, Texas, USA. [18]German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany. [19]Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany. [20]German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany. [21]Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany. [22]Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin-Institute of Psychiatry and Psychotherapy, Berlin, Germany [23]Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany [24]MR-Research in Neurosciences, Department of Cognitive Neurology, Georg-August-University Goettingen, Goettingen, Germany. [25]German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. [26]Department for Biomedical Magnetic Resonance, University of Tuebingen, Tuebingen, Germany. [27]Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany [28]Department of Diagnostic and Interventional Radiology and NuclearMedicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany [29]Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany. [30]Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany. [31]Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Germany [32]Department of Nuclear Medicine, Ludwig-Maximilian-University Munich, Munich, Germany. [33]Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. [34]Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany. [35]Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard-Karls-University, Tuebingen, Germany. [36]School of Medicine, Technical University of Munich, Department of Psychiatry and Psychotherapy, Munich, Germany. [37]University of Edinburgh and UK DRI, Edinburgh, UK. [38]German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany. [39]Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. [40]Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany. [41]Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK. [42]Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany. [43]Institute of Biomedical Engineering, Shanghai University, Shanghai, China. [44]Clinical Functional Imaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany [45]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [46]National Clinical Research Center for Geriatric Disorders, Beijing, China.
出处：
DOI： 10.1002/alz.13068
ISSN：

关键词： amyloid deposition Centiloid cross-cultural harmonization functional connectivity hippocampus insula subjective cognitive decline

摘要：
It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

基金：
National Natural Science Foundation of China, Grant/Award Number: 82020108013; National Science Fund of China for Young Scholars, Grant/Award Number: 82001773; Sino-German Center for Research Promotion, Grant/Award Numbers: GZ1370, GZ1425, GZ1567, M-0759; German Center for Neurodegenerative Diseases, Grant/Award Number: BN012; Hirnliga e.V.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学
JCR分区：
出版当年[2021]版：
Q1 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [2]German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany [3]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [4]Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany. [45]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [46]National Clinical Research Center for Geriatric Disorders, Beijing, China. [*1]Department of Psychiatry and Psychotherapy, University of Cologne,Medical Faculty, Kerpener Strasse 62, 50924 Cologne, Germany. [*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Xueyan Jiang,Xiaochen Hu,Marcel Daamen,et al.Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts[J].ALZHEIMERS & DEMENTIA.2023,19(11):4922-4934.doi:10.1002/alz.13068.
APA：
Xueyan Jiang,Xiaochen Hu,Marcel Daamen,Xiaoqi Wang,Chunqiu Fan...&Ying Han.(2023).Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts.ALZHEIMERS & DEMENTIA,19,(11)
MLA：
Xueyan Jiang,et al."Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts".ALZHEIMERS & DEMENTIA 19..11(2023):4922-4934

相关文献

[1]Individual Proportion Loss of Functional Connectivity Strength: A Novel Individual Functional Connectivity Biomarker for Subjective Cognitive Decline Populations [2]Altered functional connectivity strength in informant-reported subjective cognitive decline: A resting-state functional magnetic resonance imaging study [3]Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease [4]Subjective Cognitive Decline and Related Cognitive Deficits [5]Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease. [6]Attention in subjective cognitive decline [7]Development of subjective cognitive decline [8]Development of Subjective Cognitive Decline [9]The characterisation of subjective cognitive decline. [10]Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE.

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院