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Mongolian medicine Eerdun-Wurile promotes myocardial regeneration by regulating MVDA in zebrafish

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收录情况： ◇ ESCI

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机构： [1]Baotou Med Coll, Dept Basic Med & Forens Med, Baotou 014040, Inner Mongolia, Peoples R China [2]Baotou Med Coll, Inner Mongolia Key Lab Hypox Translat Med, Baotou 104060, Inner Mongolia, Peoples R China [3]Tradit Chinese Med Hosp Jiamusi, Dept Clin Lab, Jiamusi 154002, Heilongjiang, Peoples R China [4]Baotou Med Coll, Sch Publ Hlth, Baotou, Inner Mongolia, Peoples R China [5]Capital Med Univ, Xuanwu Hosp, Beijing Key Lab Hypox Conditioning Translat Med, Beijing, Peoples R China [6]Baotou Med Coll, Sch Pharm, Baotou 014040, Inner Mongolia, Peoples R China [7]Third Peoples Hosp Longgang Dist, Ctr Translat Med, Shenzhen, Peoples R China [8]Third Peoples Hosp Longgang Dist, Dept Lab Med, Shenzhen, Peoples R China [9]Inner Mongolia Minzu Univ, Affiliated Hosp, Tongliao 028000, Peoples R China

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关键词： Cardiomyocytes Regeneration and repair MVDA Proliferation

摘要：

Myocardial infarction (MI) is a leading cause of death and disability worldwide. The promotion of myocardial regeneration is a promising therapeutic strategy for acute MI. Using a zebrafish ventricular ablation system, we found that the Mongolian traditional medicine Eerdun-Wurile (EW) promotes myocardial regeneration in zebrafish. EW treatment significantly accelerated proliferation of myocardial cells and improved cardiac function. Transcriptome sequencing revealed a significant decrease in mevalonate diphosphate decarboxylase a (mvda) expression in the metronidazole-induced ventricular ablation group, whereas mvda expression was restored in the EW group. mvda knockdown using morpholino oligonucleotides reversed the EW-mediated myocardial regeneration, whereas mvda overexpression enhanced the regenerative ability. In conclusion, EW may promote zebrafish myocardial regeneration, accelerate myocardial cell proliferation, and improve cardiac function by upregulating mvda expression. Our data partially revealed the molecular mechanism by which EW promotes myocardial regeneration and repair, and provides experimental data and novel insights for advancing MI treatment.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程 3 区细胞生物学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区细胞与组织工程 3 区细胞生物学

JCR分区：

出版当年[2023]版：

Q2 CELL & TISSUE ENGINEERING Q2 CELL BIOLOGY

最新[2024]版：

Q2 CELL & TISSUE ENGINEERING Q2 CELL BIOLOGY

影响因子： 4.7 最新[2024版] 0 最新五年平均 4 出版当年[2023版] 0 出版当年五年平均 0 出版前一年[2022版] 4.7 出版后一年[2024版]

第一作者：

第一作者机构： [1]Baotou Med Coll, Dept Basic Med & Forens Med, Baotou 014040, Inner Mongolia, Peoples R China [2]Baotou Med Coll, Inner Mongolia Key Lab Hypox Translat Med, Baotou 104060, Inner Mongolia, Peoples R China

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通讯作者：

通讯机构： [1]Baotou Med Coll, Dept Basic Med & Forens Med, Baotou 014040, Inner Mongolia, Peoples R China [2]Baotou Med Coll, Inner Mongolia Key Lab Hypox Translat Med, Baotou 104060, Inner Mongolia, Peoples R China [5]Capital Med Univ, Xuanwu Hosp, Beijing Key Lab Hypox Conditioning Translat Med, Beijing, Peoples R China [6]Baotou Med Coll, Sch Pharm, Baotou 014040, Inner Mongolia, Peoples R China

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