机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou 221000, Jiangsu Province, China[3]Department of Neurology, Xuzhou Medical University Affiliated Hospital, No. 99 Huaihai Road, Xuzhou 221000, Jiangsu Province, China[4]Institute of Neuroscience, Soochow University, Suzhou 215123, China[5]Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China
EGb-761 is commonly used as a treatment for ischemic brain injury, neurodegenerative diseases and some types of tumors (Christen and Maixent, in Cell Mol Biol 48(6):601-611, 2002). However, it is unclear whether EGb-761 affects the proliferation of cells exposed to fluoride. In this study, the proliferation and apoptosis of PC-12 cells exposed to fluoride were investigated and EGb-761 was used to protect PC-12 cells against the effects of fluoride. We found that the canonical Wnt signaling pathway was involved in the anti-proliferation of PC-12 cells exposed to fluoride. Furthermore, the results also showed that EGb-761 could attenuate the anti-proliferative activity of fluoride via DDK1 in PC-12 cells. This study may provide a new method for protecting against the inhibition of cell proliferation induced by fluoride.
基金：
This study was supported by BK20151159
from the Natural Science Foundation of Jiangsu Province, China,
Project 81501185 of National Natural Science Foundation of China,
Xuzhou Medical Talents Project and Xuzhou technological and scientific
project No. KC14SH50.
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou 221000, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[4]Institute of Neuroscience, Soochow University, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Cai-Yi Zhang,Rui Chen,Fen Wang,et al.EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells[J].NEUROCHEMICAL RESEARCH.2017,42(2):606-614.doi:10.1007/s11064-016-2115-6.
APA：
Cai-Yi Zhang,Rui Chen,Fen Wang,Chao Ren,Peng Zhang...&Chun-feng Liu.(2017).EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells.NEUROCHEMICAL RESEARCH,42,(2)
MLA：
Cai-Yi Zhang,et al."EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells".NEUROCHEMICAL RESEARCH 42..2(2017):606-614
