机构：[a]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China[b]Laboratory of Aging and Nervous Diseases, Institute of Neuroscience, Soochow University, Suzhou 215004, China[c]First Clinical Medical School of Yangzhou University, Yangzhou 225001, China
The aim of the present study was to explore the neuroprotective effects and mechanisms of action of DL-3-n-butylphthalide (NBP) in a 1-methyl-4-phenylpyridiniumion (MPP+)-induced cellular model of Parkinson's disease (PD). NBP was extracted from seeds of Apium graveolens Linn. (Chinese celery). MPP+ treatment of PC12 cells caused reduced viability, formation of reactive oxygen, and disruption of mitochondrial membrane potential. Our results indicated that NBP reduced the cytotoxicity of MPP+ by suppressing the mitochondrial permeability transition, reducing oxidative stress, and increasing the cellular GSH content. NBP also reduced the accumulation of alpha-synuclein, the main component of Lewy bodies. Given that NBP is safe and currently used in clinical trials for stroke patients, NBP will likely be a promising chemical for the treatment of PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
基金：
This work was supported by the Suzhou Social Progress Foundation
(SS0701), and the Jiangsu Province Foundation of China
(07KJB320109).
第一作者机构：[a]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China[c]First Clinical Medical School of Yangzhou University, Yangzhou 225001, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Jin-zhong Huang,Ying-zhu Chen,Min Su,et al.DL-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP+-induced cellular model of Parkinson's disease[J].NEUROSCIENCE LETTERS.2010,475(2):89-94.doi:10.1016/j.neulet.2010.03.053.
APA：
Jin-zhong Huang,Ying-zhu Chen,Min Su,Hui-fen Zheng,Ya-ping Yang...&Chun-Feng Liu.(2010).DL-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP+-induced cellular model of Parkinson's disease.NEUROSCIENCE LETTERS,475,(2)
MLA：
Jin-zhong Huang,et al."DL-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP+-induced cellular model of Parkinson's disease".NEUROSCIENCE LETTERS 475..2(2010):89-94
