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Free-breathing, non-ECG, continuous myocardial T-1 mapping with cardiovascular magnetic resonance multitasking

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机构: [1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. [2]Department of Bioengineering, University of California, Los Angeles, California. [3]Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California. [4]Department of Radiology, Xuanwu Hospital, Beijing, China.
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关键词: cardiac imaging T-1 mapping tissue characterization

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Purpose: To evaluate the accuracy and repeatability of a free-breathing, non-electrocardiogram (ECG), continuous myocardial T-1 and extracellular volume (ECV) mapping technique adapted from the Multitasking framework. Methods: The Multitasking framework is adapted to quantify both myocardial native T-1 and ECV with a free-breathing, non-ECG, continuous acquisition T-1 mapping method. We acquire interleaved high-spatial resolution image data and high-temporal resolution auxiliary data following inversion-recovery pulses at set intervals and perform low-rank tensor imaging to reconstruct images at 344 inversion times, 20 cardiac phases, and 6 respiratory phases. The accuracy and repeatability of Multitasking T-1 mapping in generating native T-1 and ECV maps are compared with conventional techniques in a phantom, a simulation, 12 healthy subjects, and 10 acute myocardial infarction patients. Results: In phantoms, Multitasking T-1 mapping correlated strongly with the gold-standard spin-echo inversion recovery (R-2 = 0.99). A simulation study demonstrated that Multitasking T-1 mapping has similar myocardial sharpness to the fully sampled ground truth. In vivo native T-1 and ECV values from Multitasking T-1 mapping agree well with conventional MOLLI values and show good repeatability for native T-1 and ECV mapping for 60 seconds, 30 seconds, or 15 seconds of data. Multitasking native T-1 and ECV in myocardial infarction patients correlate positively with values from MOLLI. Conclusion: Multitasking T-1 mapping can quantify native T-1 and ECV in the myocardium with free-breathing, non-ECG, continuous scans with good image quality and good repeatability in vivo in healthy subjects, and correlation with MOLLI T-1 and ECV in acute myocardial infarction patients.

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出版当年[2018]版:
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 核医学
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出版当年[2017]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者:
第一作者机构: [1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California. [2]Department of Bioengineering, University of California, Los Angeles, California. [3]Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
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通讯机构: [*1]Biomedical Imaging Research Institute, Cedars‐Sinai Medical Center, 8700 Beverly Blvd.,PACT400, Los Angeles, CA 90048.
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