机构:[a]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing Institute of Functional Neurosurgery, Beijing, China神经外科首都医科大学宣武医院[b]Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China
Background: Motor cortex stimulation (MCS) has been used in the treatment of chronic neuropathic pain for more than 25 years. However, the mechanisms and outcome predictors still represent major challenges. Objectives: To investigate outcome predictors and potential mechanisms of MCS on central post-stroke pain (CPSP). Material and Methods: 16 CPSP patients were analyzed at our center. The pain intensity was assessed using a visual analog scale (VAS) before surgery and at the last follow-up. The Neuropathic Pain Symptom Inventory (NPSI) was used to assess pain intensity, analyze outcome predictors, and indicate potential mechanisms of MCS. Results: The mean VAS score before surgery (8.0 +/- 0.7) was significantly higher than that of the last follow-up (5.3 +/- 2.4, p < 0.001). Similarly, the mean total NPSI score before MCS (30.6 +/- 12.2) was significantly reduced at the last follow-up (25.2 +/- 15.1, p = 0.01). An analysis of the NPSI subscores revealed a significant association between burning pain relief and effective results (p = 0.041, Fisher's exact test). Conclusions: Burning pain relief might predict long-term results for the therapeutic use of MCS in CPSP. The substantia gelatinosa may play an important role in the modulation of pain relief mediated by MCS. (C) 2018 S. Karger AG, Basel
第一作者机构:[a]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing Institute of Functional Neurosurgery, Beijing, China
通讯作者:
通讯机构:[*1]No. 45 Changchun Street Xicheng District, Beijing,China
推荐引用方式(GB/T 7714):
Xiaolei Zhang,Hongwei Zhu,Wei Tao,et al.Motor Cortex Stimulation Therapy for Relief of Central Post-Stroke Pain: A Retrospective Study with Neuropathic Pain Symptom Inventory[J].STEREOTACTIC AND FUNCTIONAL NEUROSURGERY.2018,96(4):239-243.doi:10.1159/000492056.
APA:
Xiaolei Zhang,Hongwei Zhu,Wei Tao,Yongjie Li&Yongsheng Hu.(2018).Motor Cortex Stimulation Therapy for Relief of Central Post-Stroke Pain: A Retrospective Study with Neuropathic Pain Symptom Inventory.STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,96,(4)
MLA:
Xiaolei Zhang,et al."Motor Cortex Stimulation Therapy for Relief of Central Post-Stroke Pain: A Retrospective Study with Neuropathic Pain Symptom Inventory".STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 96..4(2018):239-243