机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[3]National Clinical Research Center for Geriatric Disorders, Beijing, China[4]Beijing Institute of Geriatrics, Beijing, China[5]PKUCare Rehabilitation Hospital, Beijing, China[6]Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China[7]Radiological Sciences, Division of Clinical Neuroscience, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom[8]Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom[9]School of Information Science and Engineering, Yanshan University, Qinhuangdao, China[10]The Key Laboratory of Software Engineering of Hebei Province, Yanshan University, Qinhuangdao, China
We analyzed topology of brain functional networks in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment. We recruited T2DM patients without mild cognitive impairment (4 males and 8 females) and healthy control subjects (8 males and 16 females) to undergo cognitive testing and resting-state functional magnetic resonance imaging. Graph theoretical analysis of functional brain networks revealed abnormal small-world architecture in T2DM patients as compared to control subjects. The functional brain networks of T2DM patients showed increased path length, decreased global efficiency and disrupted long-distance connections. Moreover, reduced nodal characteristics were distributed in the frontal, parietal and temporal lobes, while increased nodal characteristics were distributed in the frontal, occipital lobes, and basal ganglia in the T2DM patients. The disrupted topological properties correlated with cognitive performance of T2DM patients. These findings demonstrate altered topological organization of functional brain networks in T2DM patients without mild cognitive impairment.
基金：
The National Key Research and Development Program of China (2016YFC1306300),
National Natural Science Foundation of China (Grant No. 31371007, 81430037, 61633018, 61503326, 61603399),
Beijing Nature Science Foundation (7161009),
Beijing Municipal Science & Technology Commission (Z161100002616020),
Fundamental and Clinical Cooperative Research Program of Capital Medical University (16JL-L08),
Health and Family Planning Commission of Shunyi District Beijing,
Opening Foundation of Key Laboratory of Behavioral Science, Chinese Academy of Sciences,
Natural Science Foundation of Hebei Province in China (F2016203343).
第一作者机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[3]National Clinical Research Center for Geriatric Disorders, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[3]National Clinical Research Center for Geriatric Disorders, Beijing, China[4]Beijing Institute of Geriatrics, Beijing, China[5]PKUCare Rehabilitation Hospital, Beijing, China[6]Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
推荐引用方式(GB/T 7714)：
Guan-Qun Chen,Xin Zhang,Yue Xing,et al.Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment[J].ONCOTARGET.2017,8(61):104560-104570.doi:10.18632/oncotarget.21282.
APA：
Guan-Qun Chen,Xin Zhang,Yue Xing,Dong Wen,Guang-Bin Cui&Ying Han.(2017).Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment.ONCOTARGET,8,(61)
MLA：
Guan-Qun Chen,et al."Resting-state functional magnetic resonance imaging shows altered brain network topology in Type 2 diabetic patients without cognitive impairment".ONCOTARGET 8..61(2017):104560-104570
医学