机构：[1]Capital Med Univ, Inst Vasc Surg, Xuan Wu Hosp, Dept Vasc Surg, Beijing, Peoples R China首都医科大学宣武医院[2]Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA
Carotid stenosis is a narrowing or constriction of the inner surface of the carotid artery, usually caused by atherosclerosis. In the past decades, carotid angioplasty and stenting (CAS) has been developed into a credible option for the patients with carotid stenosis. However, restenosis remains a severe and unsolved issue after CAS treatment. Currently, the molecular mechanisms involved in the restenosis are still largely unclear. In this study, we found that the double-strand DNA breaks (DSBs) were induced by oxidative stress in the human carotid artery with restenosis by examining the level of gamma H2AX in the artery tissues. We further analyzed the activation of DNA damage repair pathways in the carotid restenosis. Our results suggest that non-homologues end joining (NHEJ), but not homologous recombination (HR), is mainly activated in the artery tissues with restenosis. Our results may provide clues to develop a new therapeutic strategy for carotid artery restenosis following CAS treatment.
基金：
National Institute of Health [CA132755, CA130899]; University of Michigan Cancer Center; GI Peptide Research Center; Department of Defense
第一作者机构：[1]Capital Med Univ, Inst Vasc Surg, Xuan Wu Hosp, Dept Vasc Surg, Beijing, Peoples R China
通讯作者：
通讯机构：[2]Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA
推荐引用方式(GB/T 7714)：
Luo T.,Cui S.,Bian C.,et al.DNA DOUBLE-STRAND BREAK REPAIR IS ACTIVATED IN CAROTID ARTERY RESTENOSIS[J].CELLULAR AND MOLECULAR BIOLOGY.2013,59:1869-1875.doi:10.1170/222.
APA：
Luo, T.,Cui, S.,Bian, C.&Yu, X..(2013).DNA DOUBLE-STRAND BREAK REPAIR IS ACTIVATED IN CAROTID ARTERY RESTENOSIS.CELLULAR AND MOLECULAR BIOLOGY,59,
MLA：
Luo, T.,et al."DNA DOUBLE-STRAND BREAK REPAIR IS ACTIVATED IN CAROTID ARTERY RESTENOSIS".CELLULAR AND MOLECULAR BIOLOGY 59.(2013):1869-1875
