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Abnormal recovery function of somatosensory evoked potentials in patients with primary insomnia

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchunjie Road, Beijing 100053, China

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关键词： Primary insomnia Somatosensory evoked potential Recovery function Median nerve Cortical excitability

摘要：

Neurobiological correlates underlying insomnia are poorly understood. The hyperarousal of the central nervous system indicates that cortical excitability may be abnormal in patients with insomnia. The purpose of the present study was to investigate changes in cortical excitability by examining the recovery function of median nerve somatosensory evoked potentials (SEPs) in patients with primary insomia (PI). We studied the recovery function of median nerve SEPs in 12 medication-naive PI patients and in 12 age- and sex-matched healthy subjects. SEPs in response to single stimulus and paired stimuli at interstimulus intervals (ISIs) of 20, 60, 100 and 150 ms were recorded. The recovery function of the cortical components of frontal P20 and parietal N20 showed significantly reduced suppression in PI patients as compared to healthy controls. In conclusion, this is the first study investigating changes in cortical excitability in PI patients by examining the recovery function of median nerve SEPs. The present study suggests that cortical excitability is increased in PI patients. Dysfunction of inhibitory GABAergic intemeurons of the cerebral cortex might contribute to the increased cortical excitability in PI patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2011]版：

大类 | 3 区医学

小类 | 3 区精神病学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区精神病学

JCR分区：

出版当年[2010]版：

Q1 PSYCHIATRY Q2 PSYCHIATRY

最新[2023]版：

Q1 PSYCHIATRY

影响因子： 4.2 最新[2023版] 5.3 最新五年平均 2.803 出版当年[2010版] 2.936 出版当年五年平均 2.373 出版前一年[2009版] 2.524 出版后一年[2011版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchunjie Road, Beijing 100053, China

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchunjie Road, Beijing 100053, China

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