机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45, Chang-Chun Street, Xuanwu District, Beijing 100053, China放射科首都医科大学宣武医院[b]State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China[c]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45, Chang-Chun Street, Xuanwu District, Beijing 100053, China神经内科首都医科大学宣武医院
Whether patients with tuberous sclerosis complex (TSC) have brain normal-appearing white matter (NAWM) damage and whether such damage contributes to their intellectual disability were examined in 15 TSC patients and 15 gender- and age-matched healthy controls using diffusion tensor imaging (DTI). Histogram and region of interest (ROI) analyses of the mean diffusivity (MD) and fractional anisotropy (FA) were performed in the NAWM. Correlations between diffusion indices and the full-scale intelligence quotient (FSIQ) and normalized lesion volume were also investigated. Compared with controls, both histogram and ROI analyses showed significant (P<.05) increased MD and decreased FA in the NAWM of TSC patients. In TSC patients, some of the histogram- and ROI-derived diffusion indices of the NAWM were correlated with FSIQ (P<.01), but none of them were correlated with the normalized lesion volume. These findings indicate that TSC patients have occult damage in the NAWM, which might be an important neural basis for intellectual disability in these patients. (C) 2008 Elsevier Inc. All rights reserved.
基金：
Natural Science Foundation of China (No. 30670601),
Beijing Scientific and Technological New Star Program (2005B21),
and the Foundation of President of the Chinese Academy of Sciences.
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2008]版：
无
最新[2023]版：
大类|2 区心理学
小类|2 区心理学：综合
第一作者：
第一作者机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45, Chang-Chun Street, Xuanwu District, Beijing 100053, China
通讯作者：
通讯机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45, Chang-Chun Street, Xuanwu District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Chunshui Yu,Fuchun Lin,Li Zhao,et al.Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex[J].INTELLIGENCE.2009,37(2):doi:10.1016/j.intell.2008.06.001.
APA：
Chunshui Yu,Fuchun Lin,Li Zhao,Jing Ye&Wen Qin.(2009).Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex.INTELLIGENCE,37,(2)
MLA：
Chunshui Yu,et al."Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex".INTELLIGENCE 37..2(2009)
