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RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort

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机构: [1]Department of Orthopedic Trauma, the Affiliated Hospital of Guizhou Medical University, No 28, Guiyi Street, Guiyang City 550001, China [2]Department of Rehabilitation, Jizhong Energy Xingtai MIG General Hospital, No 202, Bayi Street, Xingtai City 054001, China [3]Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
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关键词: Neurotrophin TRK receptor signaling pathway Peripheral blood RNA sequencing Spinal cord injury

摘要:
Spinal cord injury (SCI) can be lethal; however, the precise mechanisms underlying healing are unclear, limiting the development of effective therapies. In this study, the molecular mechanisms involved in SCI were investigated. Clinical peripheral blood samples from normal individuals and patients with incomplete SCI (ISCI) and complete SCI (CSCI) were analyzed by RNA-Seq. The expression levels of EPHA4, CDK16, BAD, MAP2 Normal 2, EGR, and RHOB differed significantly between the SCI group and normal individuals, and these results were verified by q-PCR. A gene ontology (GO) enrichment analysis showed that differentially expressed genes were mostly enriched for the neurotrophin TRK receptor signaling pathway. We verified the expression of neurotrophic factors and found that they were all expressed most highly in the SCI group. The results of this study demonstrate that neurotrophic factors are highly expressed after SCI and the neurotrophin TRK receptor signaling pathway may be involved in the initiation of nerve system regeneration. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 4 区 生化与分子生物学 4 区 神经科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 生化与分子生物学 4 区 神经科学
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出版当年[2017]版:
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 NEUROSCIENCES
最新[2023]版:
Q2 NEUROSCIENCES Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [1]Department of Orthopedic Trauma, the Affiliated Hospital of Guizhou Medical University, No 28, Guiyi Street, Guiyang City 550001, China
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通讯机构: [1]Department of Orthopedic Trauma, the Affiliated Hospital of Guizhou Medical University, No 28, Guiyi Street, Guiyang City 550001, China
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