机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[2]Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,首都医科大学附属天坛医院[3]China National Clinical Research Center for Neurological Diseases, Beijing, China,[4]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[5]The Second Affiliated Hospital, South China University of Technology, Guangzhou, China
Theta burst stimulation (TBS) is a powerful variant of repetitive transcranial magnetic stimulation (rTMS), making it potentially useful for the treatment of swallowing disorders. However, how dose TBS modulate human swallowing cortical excitability remains unclear. Here, we aim to measure the after-effects of spontaneous brain activity at resting-state using the regional homogeneity (ReHo) approach in healthy subjects who underwent different TBS protocols over the suprahyoid muscle cortex. Sixty healthy subjects (23.45 +/- 2.73 years, 30 males) were randomized into three groups which completed different TBS protocols. The TMS coil was applied over the cortex of the suprahyoid muscles. Data of resting-state functional MRI (Rs-fMRI) of the subjects were acquired before and after TBS. The ReHo was compared across sessions [continuous TBS (cTBS), intermittent TBS (iTBS) and cTBS/TBS] and runs (pre/post TBS). In the comparison between pre- and post-TBS, increased ReHo was observed in the right lingual gyrus and right precuneus and decreased ReHo in the left cingulate gyrus in the cTBS group. In the iTBS group, increased ReHo values were seen in the pre-/postcentral gyrus and cuneus, and decreased ReHo was observed in the left cerebellum, brainstem, bilateral temporal gyrus, insula and left inferior frontal gyrus. In the cTBS/iTBS group, increased ReHo was found in the precuneus and decreased ReHo in the right cerebellum posterior lobe, left anterior cerebellum lobe, and right inferior frontal gyrus. In the post-TBS inter-groups comparison, increased ReHo was seen in right middle occipital gyrus and decreased ReHo in right middle frontal gyrus and right postcentral gyrus (cTBS vs. cTBS/iTBS). Increased ReHo was shown in left inferior parietal lobule and left middle frontal gyrus (cTBS vs. iTBS). Increased ReHo was shown in right medial superior frontal gyrus and decreased ReHo in right cuneus (cTBS/iTBS vs. iTBS). Our findings indicate cTBS had no significant influence on ReHo in the primary sensorimotor cortex, iTBS facilitates an increased ReHo in the bilateral sensorimotor cortex and a decreased ReHo in multiple subcortical areas, and no reverse effect exhibits when iTBS followed the contralateral cTBS over the suprahyoid motor cortex. The results provide a novel insight into the neural mechanisms of TBS on swallowing cortex.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China [81871846, 81371441, 81572230]; Guangdong Provincial Science and Technology Program [2013B051000036, 2014B020212001]; Guangzhou Municipal Science and Technology Program [2016201604030036]; Science and Technology Planning Project of Guangzhou [201804010032]
第一作者机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[4]Department of Rehabilitation Medicine, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China,[5]The Second Affiliated Hospital, South China University of Technology, Guangzhou, China
推荐引用方式(GB/T 7714)：
Xiuhang Ruan,Guoqin Zhang,Guangqing Xu,et al.The After-Effects of Theta Burst Stimulation Over the Cortex of the Suprahyoid Muscle on Regional Homogeneity in Healthy Subjects[J].FRONTIERS IN BEHAVIORAL NEUROSCIENCE.2019,13:-.doi:10.3389/fnbeh.2019.00035.
APA：
Xiuhang Ruan,Guoqin Zhang,Guangqing Xu,Cuihua Gao,Lingling Liu...&Xinhua Wei.(2019).The After-Effects of Theta Burst Stimulation Over the Cortex of the Suprahyoid Muscle on Regional Homogeneity in Healthy Subjects.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,13,
MLA：
Xiuhang Ruan,et al."The After-Effects of Theta Burst Stimulation Over the Cortex of the Suprahyoid Muscle on Regional Homogeneity in Healthy Subjects".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 13.(2019):-
